Guoping Feng

Guoping Feng
Born	Zhejiang Province, China
Fields	Neurobiology
Institutions	Duke University Massachusetts Institute of Technology Broad Institute
Alma mater	Zhejiang University (B.M.S. 1982) Second Military Medical University (M.S. 1985) State University of New York at Potsdam (Ph.D. 1994)
Doctoral advisor	Linda Hall
Known for	Animal models of psychiatric disease
Notable awards	Beckman Young Investigator Award (2002) McKnight Neuroscience of Brain Disorders Award (2006) Hartwell Individual Biomedical Research Award (2006) Gill Young Investigator Award (2012)[1]

Guoping Feng is the Poitras Professor of Neuroscience at the McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT^[2][3] and member of the Stanley Center for Psychiatric Research at Broad Institute most notable for studying the synaptic mechanisms underlying psychiatric disease.^[4] In addition to developing many genetic-based imaging tools for the study of molecular mechanisms in the brain,^[5] he has generated and characterized rodent models of obsessive-compulsive disorder,^[6][7] autism spectrum disorders,^[8] and schizophrenia.^[9] Feng has also shown that some autism-like behaviors can be corrected in adult mice by manipulating the expression of the Shank3 gene.^[10]

Selected publications

• Mei J, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G. (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. . Nature doi:10.1038/nature16971
• Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2012) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437–442
• Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448: 894–900
• Feng G et al. (2000) Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 28: 41–51

References

1. http://newsinfo.iu.edu/news-archive/23076.html
2. McGovern Institute: Guoping Feng (accessed 6 February 2016)
3. MIT: Feng, Guoping (accessed 6 February 2016)
4. http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
5. http://www.sciencedaily.com/releases/2012/10/121017131843.htm
6. http://www.nih.gov/news-events/news-releases/gene-triggers-obsessive-compulsive-disorder-syndrome-mice
7. http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
8. http://cen.acs.org/articles/90/i10/Inner-Workings-Autism.html?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+biological_scene+%28Chemical+%26+Engineering+News%3A+Biological+SCENE%29
9. http://news.mit.edu/2015/shank3-gene-autism-schizophrenia-1210
10. http://www.ibtimes.co.uk/autism-behaviours-reversed-mice-by-switching-shank3-gene-adulthood-1544661