Gynostemma pentaphyllum

Gynostemma pentaphyllum
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Rosids
Order: Cucurbitales
Family: Cucurbitaceae
Subfamily: Nhandiroboideae (syn. Zanonioideae)
Tribe: Zanonieae
Subtribe: Gomphogyninae
Genus: Gynostemma
Species: G. pentaphyllum
Binomial name
Gynostemma pentaphyllum
(Thunb.) Makino 1902
Baby jiaogulan plants

Gynostemma pentaphyllum, also called jiaogulan (Simplified Chinese: 绞股蓝, Traditional Chinese: 絞股藍, Pinyin: jiǎogǔlán), literally "stranded blue plant", is a dioecious, herbaceous climbing vine of the family Cucurbitaceae (cucumber or gourd family) indigenous to the southern reaches of China, northern Vietnam, southern Korea, and Japan. Jiaogulan is best known as an herbal medicine reputed to have powerful antioxidant and adaptogenic effects purported to increase longevity.[1] Pharmacological research has indicated a number of therapeutic qualities of Jiaogulan, such as lowering cholesterol and high blood pressure, and strengthening immunity.

Description

Jiaogulan belongs to the genus Gynostemma, in the family Cucurbitaceae, which includes cucumbers, gourds, and melons, although it lacks the characteristic fruit. It is a climbing vine, attaching itself to supports using tendrils. The serrated leaflets commonly grow in groups of five (as in G. pentaphyllum) although some species can have groups of three or seven leaflets. The plant is dioecious, meaning each plant exists either as male or female. Therefore, if seeds are desired, both a male and female plant must be grown.

Taxonomy

Gynostemma pentaphyllum is known as Jiaogulan (Chinese: 绞股蓝 "twisting crotched indigo plant") in China. The plant was first described in 1406 CE by Zhu Xiao, who presented a description and sketch in the book Materia Medica for Famine as a survival food rather than a medicinal herb.[2] The earliest record of jiaogulan's use as a drug comes from herbalist Li Shizhen's book Compendium of Materia Medica published in 1578, identifying jiaogulan for treating various ailments such as hematuria, edema in the pharynx and neck, tumors, and trauma. While Li Shi-Zhen had confused jiaogulan with an analogous herb Wulianmei, in 1848 Wu Qi-Jun rectified this confusion in Textual Investigation of Herbal Plants, which also added more information on medicinal usage.[3]

Modern recognition of the plant outside of China originated from research in sugar substitutes. In the 1970s, while analyzing the sweet component of the jiaogulan plant (known as amachazuru in Japan), Masahiro Nagai discovered chemical compounds identical to some of those found in Panax ginseng, an unrelated plant.[4] Afterward, Tsunematsu Takemoto reported that jiaogulan contains four saponins identical to those in Panax ginseng as well as seventeen other similar saponins. Over the next decade 82 saponins (gypenosides) were identified in jiaogulan, compared to the 28 (ginsenosides) found in Panax ginseng.

Distribution and habitat

Over thirty species of Gynostemma are known to grow throughout China, predominantly in the Southwest, although most species exist in at least one other country. The species G. pentaphyllum has the widest distribution outside of China, ranging from India to Southeast Asia to Japan and Korea.

Jiaogulan is a vine hardy to USDA zone 8 in which it may grow as a short lived perennial plant. It can be grown as an annual in most temperate climates, in well-drained soil with full sun. It does not grow well in cold climates with temperatures below freezing.

Toxicity

Jiaogulan does not show toxicity.[5][6] However, several related plants in the Cucurbitaceae (cucumber) family contain Cucurbitacin compounds, which are responsible for the bitter taste in some edible plants of this family but are highly toxic to mammals.[7]

Use in ethnomedicine

The plant is best known for its use as an herbal medicine. Jiaogulan is most often consumed as an herbal tea, and is also available as an alcohol extract and in capsule or pill form.[8] It has not seen widespread use in traditional Chinese medicine (TCM) because it grows far from central China where TCM evolved; consequently, it was not included in the standard pharmacopoeia of the TCM system. Until recently it was a locally-known herb used primarily in mountainous regions of southern China and in northern Vietnam. It is described by the local inhabitants as the "immortality herb", because people within Guizhou Province, where jiaogulan herbal teas are consumed regularly, are said to have a history of unusual longevity.[9][10]

In the European Union Jiaogulan is considered Novel Food since a controversial court ruling in 2012, which since then prohibits its sale as food. [11]

Pharmacological research

Antioxidant

Jiaogulan has been found to increase superoxide dismutase (SOD), which is a powerful endogenous cellular antioxidant. Studies have found it increases the activities of macrophages, T lymphocytes and natural killer cells and that it acts as a tumor inhibitor.[12]

Adaptogen

Jiaogulan is known as an adaptogen, which is an herb reputed to help the body to maintain optimal homeostasis.[13] Its chemical constituents include the triterpenoid saponins gypenosides which are closely structurally related to the ginsenosides which are present in ginseng.[14] Most research has been done since the 1960s when the Chinese realized that it might be an inexpensive source of adaptogenic compounds, removing pressure from the ginseng stock. Purported adaptogenic effects include regulating blood pressure and the immune system, improving stamina and endurance.[15] Jiaogulan is also believed to be useful in combination with codonopsis for jet lag and altitude sickness.[10]

Blood pressure

The adaptogenic nature of gypenosides have been found to keep blood pressure in a normal range. In vitro studies indicate that jiaogulan stimulates the release of nitric oxide in isolated heart cells; this is one proposed mechanism by which jiaogulan reduces high blood pressure.[16] In a double-blind study, gypenosides administered to those with Grade II hypertension showed 82% effectiveness in reducing hypertension, compared to 46% for ginseng and 93% for indapamide (a hypertension medication).[17]

Cardiovascular functions

Animal studies as well as clinical testing on humans suggest that jiaogulan, when combined with other herbs, has beneficial effects on cardiovascular system, increasing heart stroke volume, coronary flow, and cardiac output while reducing the heart rate, without affecting arterial pressure.[18][19]

Cholesterol reduction

Numerous clinical studies in Chinese medical literature have shown that jiagolan lowers serum cholesterol,[20] triglycerides, and LDL (the "bad" cholesterol) while raising HDL ("good" cholesterol) levels, with reported effectiveness rates ranging from 67% to 93% on over 980 patients with hyperlipemia.[21]

Diabetes

Gynostemma pentaphyllum tea has been studied in a randomized controlled trial in type 2 diabetic patients.[22] It may have potential as a hypoglycemic treatment to reduce blood glucose.[23]

Hepatoprotection

Jiaogulan is a source of ampelopsin, a compound which displays some hepatoprotective effects in rodent models.[24] It is a major source of the compound for the supplement industry.

Alternate names

Western languages such as English and German commonly refer to the plant as jiaogulan. Other names include:

References

  1. ↑ Blumert, Michael; Jialiu Liu (2003). Jiaogulan: China's "Immortality" Herb. Badger, CA: Torchlight Publishing. p. 12. ISBN 1-887089-16-0. Cite uses deprecated parameter |coauthors= (help)
  2. ↑ Cheng JG, et al. (1990). "Investigation of the plant jiaogulan and its analogous herb, Wulianmei". Zhong Cao Yao 21 (9): 424.
  3. ↑ Blumert, p. 21.
  4. ↑ Nagai, Masahiro (November 1976). Abstracts of Papers, 23d Meeting of the Japanese Society of Pharmacognosy. Japanese Society of Pharmacognosy. p. 37.
  5. ↑ Attawish A, Chivapat S, Phadungpat S, Bansiddhi J, Techadamrongsin Y, Mitrijit O, Chaorai B, Chavalittumrong P (September 2004). "Chronic toxicity of Gynostemma pentaphyllum". Fitoterapia 75 (6): 539–51. doi:10.1016/j.fitote.2004.04.010.
  6. ↑ Choi HS, Park MS, Kim SH, Hwang BY, Lee CK, Lee MK (2010). "Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease" (PDF). Molecules 15 (4): 2814–24. doi:10.3390/molecules15042814.
  7. ↑ Sharma A, Sharma JP, Jindal R, Kaushik RM (April–June 2006). "Bottle Gourd Poisoning" (PDF). Research Letter (JK Science) 8 (2).
  8. ↑ Blumert, pp 66-70.
  9. ↑ Winston, David; Steven Maimes (April 2007). Adaptogens: Herbs for Strength, Stamina, and Stress Relief. Healing Arts Press. ISBN 978-1-59477-158-3. Contains a detailed herbal monograph on jiaogulan and highlights health benefits.
  10. 1 2 Bensky, Dan; Andrew Gamble; Steven Clavey; Erich Stöger (September 2004). Chinese Herbal Medicine: Materia Medica, 3rd Edition. Eastland Press. ISBN 978-0-939616-42-8.
  11. ↑ "Jiaogulan ist als Lebensmittel in Deutschland und somit auch in der ganzen Europäischen Union nun offiziell verboten!". www.jiaogulan-tee.net (in German). Retrieved 2016-04-27.
  12. ↑ Liu et al. (1992). "Therapeutic effect of jiaogulan on leukopenia due to irradiation and chemotherapy". Zhong Guo yi Yao Xue Bao 7 (2): 99.
  13. ↑ David Winston; Steven Maimes (2007). Adaptogens: Herbs for Strength, Stamina, and Stress Relief. Healing Arts Press. ISBN 978-1-59477-158-3.
  14. ↑ Liu SB, Lin R, Hu ZH (February 2005). "Histochemical localization of ginsenosides in Gynostemma pentaphyllum and the content changes of total gypenosides [Chinese]". Shih Yen Sheng Wu Hsueh Pao: Journal of Experimental Biology 38 (1): 54–60. PMID 15839207.
  15. ↑ "Complete Jiaogulan information from Drugs.com". Drugs.com.
  16. ↑ Tanner MA, Bu X, Steimle JA, Myers PR (1999-10-03). "The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum". Nitric Oxide 3 (5): 359–65. doi:10.1006/niox.1999.0245. PMID 10534439.
  17. ↑ Lu, GH et al. (1996). "Comparative study on anti-hypertensive effect of Gypenosides, Ginseng and Indapamide in patients with essential hypertension". Guizhou Medical Journal 20: 19–26.
  18. ↑ Chen, LF et al. (1990). "Comparison between the effects of gypenosieds and ginsegnosides on cardiac function and hemodynamics in dogs". Chinese J Pharmacol Toxicol 4 (1): 17–20.
  19. ↑ Zhou, Ning-Ya et al. (1993). "Effects of gypenosides-containing tonic on the pulmonary function in exercise workload". Journal of Guiyang Medical College 18 (4): 261.
  20. ↑ la Cour B, Mølgaard P, Yi Z (May 1995). "Traditional Chinese medicine in treatment of hyperlipidaemia". J Ethnopharmacol 46 (2): 125–9. doi:10.1016/0378-8741(95)01234-5. PMID 7650951.
  21. ↑ Blumert, p. 42.
  22. ↑ Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG (May 2010). "Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients". Hormone & Metabolic Research 42 (5): 353–7. doi:10.1055/s-0030-1248298. PMID 20213586.
  23. ↑ Hoa NK, Phan DV, Thuan ND, Ostenson CG (April 2009). "Screening of the hypoglycemic effect of eight Vietnamese herbal drugs". Methods & Findings in Experimental & Clinical Pharmacology 31 (3): 165–9. doi:10.1358/mf.2009.31.3.1362514. PMID 19536359.
  24. ↑ Hase, K; Ohsugi, M; Xiong, Q; Basnet, P; Kadota, S; Namba, T (1997). "Hepatoprotective effect of Hovenia dulcis THUNB. On experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide" (PDF). Biological & Pharmaceutical Bulletin 20 (4): 381–5. doi:10.1248/bpb.20.381. PMID 9145214.

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