H1FOO

H1 histone family, member O, oocyte-specific
Identifiers
Symbols	H1FOO ; H1.8; osH1
External IDs	MGI: 2176207 HomoloGene: 51377 GeneCards: H1FOO Gene
Gene ontology Molecular function • nucleosomal DNA binding Cellular component • nucleosome • female germ cell nucleus • nucleus • nucleolus • cytoplasm • extracellular exosome Biological process • nucleosome assembly • nucleosome positioning • regulation of DNA methylation • meiotic cell cycle • negative regulation of stem cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	132243	171506
Ensembl	ENSG00000178804	ENSMUSG00000042279
UniProt	Q8IZA3	Q8VIK3
RefSeq (mRNA)	NM_001308262	NM_138311
RefSeq (protein)	NP_001295191	NP_612184
Location (UCSC)	Chr 3: 129.54 – 129.55 Mb	Chr 6: 115.94 – 115.95 Mb
PubMed search

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.^[1][2]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.^[2]

It incorporates into sperm chromatin after fertilisation.^[3]

References

1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
2. "Entrez Gene: H1 histone family".
3. Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

Further reading

• Teranishi T, Tanaka M, Kimoto S, et al. (2004). "Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer.". Dev. Biol. 266 (1): 76–86. doi:10.1016/j.ydbio.2003.10.004. PMID 14729479.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka Y, Kato S, Tanaka M, et al. (2003). "Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte". Biochem. Biophys. Res. Commun. 304 (2): 351–7. doi:10.1016/S0006-291X(03)00610-7. PMID 12711322.
• Tanaka M, Kihara M, Hennebold JD, et al. (2005). "H1FOO is coupled to the initiation of oocytic growth". Biol. Reprod. 72 (1): 135–42. doi:10.1095/biolreprod.104.032474. PMID 15371275.
• Gao S, Chung YG, Parseghian MH, et al. (2004). "Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice". Dev. Biol. 266 (1): 62–75. doi:10.1016/j.ydbio.2003.10.003. PMID 14729478.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.