H3K4me3

H3K4me3 means trimethylation of lysine 4 on histone H3 protein subunit. A lysine specific histone methyltransferases (HMT) transfers three methyl groups to histone H3. H3K4me3 is used as a histone code or, histone mark in epigenetic studies (e.g., ChIP-seq) to identify gene promoters. H3K4me3 histone modification is found in higher abundance in the cells. H3K4me3 is highly enriched at active promoters near transcription start sites (TSS).[1]

References

  1. ↑ Liang, G (2004). "Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.". Natl Acad. Sci. USA 101: 7357–7362.
This article is issued from Wikipedia - version of the Saturday, April 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.