HAGH

Hydroxyacylglutathione hydrolase
PDB rendering based on 1qh3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1QH3​, 1QH5​, 2F50​
Identifiers
Symbols	HAGH ; GLO2; GLX2; GLXII; HAGH1
External IDs	OMIM: 138760 MGI: 95745 HomoloGene: 3890 ChEMBL: 2261 GeneCards: HAGH Gene
EC number	3.1.2.6
Gene ontology Molecular function • hydroxyacylglutathione hydrolase activity • zinc ion binding Cellular component • cytoplasm • mitochondrial matrix • extracellular exosome Biological process • carbohydrate metabolic process • glutathione biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3029	14651
Ensembl	ENSG00000063854	ENSMUSG00000024158
UniProt	Q16775	Q99KB8
RefSeq (mRNA)	NM_001040427	NM_001159626
RefSeq (protein)	NP_001035517	NP_001153098
Location (UCSC)	Chr 16: 1.8 – 1.83 Mb	Chr 17: 24.84 – 24.86 Mb
PubMed search

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.^[1][2][3]

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.^[3]

References

1. Mulley JC, Callen DF (Feb 1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum Genet 74 (4): 423–4. doi:10.1007/BF00280498. PMID 3025077.
2. Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet 58 (4): 358–61. doi:10.1007/bf00282815. PMID 7327557.
3. "Entrez Gene: HAGH hydroxyacylglutathione hydrolase".

Further reading

• Kar NC, Pearson CM (1976). "Glyoxalase enzyme system in human muscular dystrophy". Clin. Chim. Acta 65 (1): 153–5. doi:10.1016/0009-8981(75)90348-4. PMID 1192606.
• Hamilton DS, Creighton DJ (1993). "Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy". J. Biol. Chem. 267 (35): 24933–6. PMID 1459997.
• Mulley JC, Barton N, Callen DF (1990). "Localisation of human PGP and HAGH genes to 16p13.3". Cytogenet. Cell Genet. 53 (2–3): 175–6. doi:10.1159/000132923. PMID 2164460.
• Talesa V, Uotila L, Koivusalo M, et al. (1988). "Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms". Biochim. Biophys. Acta 955 (1): 103–10. doi:10.1016/0167-4838(88)90183-5. PMID 3382669.
• Thornalley PJ, Bellavite P (1987). "Modification of the glyoxalase system during the functional activation of human neutrophils". Biochim. Biophys. Acta 931 (2): 120–9. doi:10.1016/0167-4889(87)90198-4. PMID 3663711.
• Valentine WN, Paglia DE, Neerhout RC, Konrad PN (1971). "Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis". Blood 36 (6): 797–808. PMID 5485124.
• Leoncini G, Maresca M, Balestrero F, et al. (1984). "Platelet glyoxalases in thrombocytosis". Scandinavian journal of haematology 33 (1): 91–4. doi:10.1111/j.1600-0609.1984.tb02216.x. PMID 6463589.
• Board PG (1980). "Genetic polymorphism of human erythrocyte glyoxalase II". Am. J. Hum. Genet. 32 (5): 690–4. PMC 1686103. PMID 7424909.
• Di Ilio C, Angelucci S, Pennelli A, et al. (1995). "Glyoxalase activities in tumor and non-tumor human urogenital tissues". Cancer Lett. 96 (2): 189–93. doi:10.1016/0304-3835(95)03928-P. PMID 7585456.
• Ridderström M, Saccucci F, Hellman U, et al. (1996). "Molecular cloning, heterologous expression, and characterization of human glyoxalase II". J. Biol. Chem. 271 (1): 319–23. doi:10.1074/jbc.271.1.319. PMID 8550579.
• Cameron AD, Ridderström M, Olin B, Mannervik B (1999). "Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue". Structure 7 (9): 1067–78. doi:10.1016/S0969-2126(99)80174-9. PMID 10508780.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Rulli A, Carli L, Romani R, et al. (2001). "Expression of glyoxalase I and II in normal and breast cancer tissues". Breast Cancer Res. Treat. 66 (1): 67–72. doi:10.1023/A:1010632919129. PMID 11368412.
• Scirè A, Saccucci F, Bertoli E, et al. (2002). "Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II". Proteins 48 (1): 126–33. doi:10.1002/prot.10149. PMID 12012344.
• Mearini E, Romani R, Mearini L, et al. (2002). "Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas". Eur. J. Cancer 38 (14): 1946–50. doi:10.1016/S0959-8049(02)00236-8. PMID 12204678.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cordell PA, Futers TS, Grant PJ, Pease RJ (2004). "The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II". J. Biol. Chem. 279 (27): 28653–61. doi:10.1074/jbc.M403470200. PMID 15117945.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.