HAPLN1

Hyaluronan and proteoglycan link protein 1
Identifiers
Symbols	HAPLN1 ; CRT1; CRTL1
External IDs	OMIM: 115435 MGI: 1337006 HomoloGene: 1420 GeneCards: HAPLN1 Gene
Gene ontology Molecular function • hyaluronic acid binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular matrix Biological process • skeletal system development • cell adhesion • central nervous system development • extracellular matrix organization • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1404	12950
Ensembl	ENSG00000145681	ENSMUSG00000021613
UniProt	P10915	Q9QUP5
RefSeq (mRNA)	NM_001884	NM_013500
RefSeq (protein)	NP_001875	NP_038528
Location (UCSC)	Chr 5: 83.64 – 83.72 Mb	Chr 13: 89.54 – 89.61 Mb
PubMed search

Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene.^[1][2][3]

Interactions

HAPLN1 has been shown to interact with Versican.^[4]

References

1. Osborne-Lawrence SL, Sinclair AK, Hicks RC, Lacey SW, Eddy RL Jr, Byers MG, Shows TB, Duby AD (Mar 1991). "Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene". Genomics 8 (3): 562–7. doi:10.1016/0888-7543(90)90044-U. PMID 2286376.
2. Dudhia J, Hardingham TE (May 1990). "The primary structure of human cartilage link protein". Nucleic Acids Res 18 (5): 1292. doi:10.1093/nar/18.5.1292. PMC 330454. PMID 2320422.
3. "Entrez Gene: HAPLN1 hyaluronan and proteoglycan link protein 1".
4. Matsumoto, Kazu; Shionyu Masafumi; Go Mitiko; Shimizu Katsuji; Shinomura Tamayuki; Kimata Koji; Watanabe Hideto (Oct 2003). "Distinct interaction of versican/PG-M with hyaluronan and link protein". J. Biol. Chem. (United States) 278 (42): 41205–12. doi:10.1074/jbc.M305060200. ISSN 0021-9258. PMID 12888576.

Further reading

• Mundlos S, Meyer R, Yamada Y, Zabel B (1992). "Distribution of cartilage proteoglycan (aggrecan) core protein and link protein gene expression during human skeletal development.". Matrix 11 (5): 339–46. doi:10.1016/s0934-8832(11)80205-2. PMID 1725805.
• Rhodes C, Savagner P, Line S, et al. (1991). "Characterization of the promoter for the rat and human link protein gene.". Nucleic Acids Res. 19 (8): 1933–9. doi:10.1093/nar/19.8.1933. PMC 328126. PMID 2030970.
• Dudhia J, Hardingham TE (1990). "The primary structure of human cartilage link protein.". Nucleic Acids Res. 18 (8): 2214. doi:10.1093/nar/18.8.2214. PMC 330736. PMID 2336413.
• Perkins SJ, Nealis AS, Dudhia J, Hardingham TE (1989). "Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein.". J. Mol. Biol. 206 (4): 737–53. doi:10.1016/0022-2836(89)90580-9. PMID 2738916.
• Nguyen Q, Murphy G, Hughes CE, et al. (1993). "Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.". Biochem. J. 295. ( Pt 2): 595–8. PMC 1134922. PMID 7694569.
• Dudhia J, Bayliss MT, Hardingham TE (1994). "Human link protein gene: structure and transcription pattern in chondrocytes.". Biochem. J. 303. ( Pt 1): 329–33. PMC 1137594. PMID 7945259.
• Guerassimov A, Zhang Y, Banerjee S, et al. (1998). "Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis.". J. Rheumatol. 25 (8): 1480–4. PMID 9712087.
• Perveen R, Hart-Holden N, Dixon MJ, et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3.". Genomics 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161.
• Hirakawa S, Oohashi T, Su WD, et al. (2000). "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.". Biochem. Biophys. Res. Commun. 276 (3): 982–9. doi:10.1006/bbrc.2000.3583. PMID 11027579.
• Pokharna HK, Pottenger LA (2000). "Glycation induced crosslinking of link proteins, in vivo and in vitro.". J. Surg. Res. 94 (1): 35–42. doi:10.1006/jsre.2000.6000. PMID 11038300.
• Milz S, Schlüter T, Putz R, et al. (2001). "Fibrocartilage in the transverse ligament of the human atlas.". Spine 26 (16): 1765–71. doi:10.1097/00007632-200108150-00007. PMID 11493848.
• Sun GW, Kobayashi H, Suzuki M, et al. (2003). "Production of cartilage link protein by human granulosa-lutein cells.". J. Endocrinol. 175 (2): 505–15. doi:10.1677/joe.0.1750505. PMID 12429048.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Spicer AP, Joo A, Bowling RA (2003). "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.". J. Biol. Chem. 278 (23): 21083–91. doi:10.1074/jbc.M213100200. PMID 12663660.
• Matsumoto K, Shionyu M, Go M, et al. (2003). "Distinct interaction of versican/PG-M with hyaluronan and link protein.". J. Biol. Chem. 278 (42): 41205–12. doi:10.1074/jbc.M305060200. PMID 12888576.
• Shi S, Grothe S, Zhang Y, et al. (2004). "Link protein has greater affinity for versican than aggrecan.". J. Biol. Chem. 279 (13): 12060–6. doi:10.1074/jbc.M310091200. PMID 14724283.
• Kou I, Ikegawa S (2005). "SOX9-dependent and -independent transcriptional regulation of human cartilage link protein.". J. Biol. Chem. 279 (49): 50942–8. doi:10.1074/jbc.M406786200. PMID 15456769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.