2-hydroxychromene-2-carboxylate isomerase

2-hydroxychromene-2-carboxylate isomerase (EC 5.99.1.4, HCCA isomerase, 2HC2CA isomerase, 2-hydroxychromene-2-carboxylic acid isomerase) is an enzyme with systematic name 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

2-hydroxy-2H-chromene-2-carboxylate

\rightleftharpoons

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

This enzyme is involved in naphthalene degradation.

References

↑ Ohmoto, T., Kinoshita, T., Moriyoshi, K., Sakai, K., Hamada, N. and Ohe, T. (1998). "Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2". J. Biochem. 124 (3): 591–597. doi:10.1093/oxfordjournals.jbchem.a022152. PMID 9722670.
↑ Keck, A., Conradt, D., Mahler, A., Stolz, A., Mattes, R. and Klein, J. (2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology 152: 1929–1940. doi:10.1099/mic.0.28783-0. PMID 16804169.
↑ Eaton, R.W. (1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". J. Bacteriol. 176 (24): 7757–7762. PMID 8002605.
↑ Thompson, L.C., Ladner, J.E., Codreanu, S.G., Harp, J., Gilliland, G.L. and Armstrong, R.N. (2007). "2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida". Biochemistry 46 (23): 6710–6722. doi:10.1021/bi700356u. PMID 17508726.

External links

2-hydroxychromene-2-carboxylate isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: topoisomerases (EC 5.99)

5.99.1	Type I topoisomerase Type II topoisomerase gyrase topoisomerase IV

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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