HCLS1

Hematopoietic cell-specific Lyn substrate 1
Identifiers
Symbols	HCLS1 ; CTTNL; HS1; lckBP1; p75
External IDs	OMIM: 601306 MGI: 104568 HomoloGene: 38034 GeneCards: HCLS1 Gene
Gene ontology Molecular function • RNA polymerase II transcription factor binding • actin binding • protein binding • SH3 domain binding • protein kinase binding • protein complex binding Cellular component • nucleus • transcription factor complex • cytoplasm • mitochondrion • membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • positive regulation of cell proliferation • response to hormone • positive regulation of phosphatidylinositol 3-kinase signaling • actin filament polymerization • erythrocyte differentiation • regulation of actin filament polymerization • positive regulation of granulocyte differentiation • positive regulation of peptidyl-serine phosphorylation • intracellular signal transduction • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of transcription factor import into nucleus • positive regulation of macrophage differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein kinase B signaling • cellular response to cytokine stimulus • negative regulation of leukocyte apoptotic process • positive regulation of actin cytoskeleton reorganization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3059	15163
Ensembl	ENSG00000180353	ENSMUSG00000022831
UniProt	P14317	P49710
RefSeq (mRNA)	NM_001292041	NM_008225
RefSeq (protein)	NP_001278970	NP_032251
Location (UCSC)	Chr 3: 121.63 – 121.66 Mb	Chr 16: 36.93 – 36.96 Mb
PubMed search

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.^[1][2][3]

Interactions

HCLS1 has been shown to interact with Caspase 3.^[4][5]

References

1. Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2-3): 175–6. doi:10.1159/000134179. PMID 8978766.
2. van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
3. "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
4. Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. (England) 364 (Pt 1): 41–7. ISSN 0264-6021. PMC 1222543. PMID 11988074.
5. Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. (United States) 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Further reading

• Kitamura D, Kaneko H, Miyagoe Y, et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.". Nucleic Acids Res. 17 (22): 9367–79. PMC 335138. PMID 2587259.
• Yamanashi Y, Okada M, Semba T, et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631–5. doi:10.1073/pnas.90.8.3631. PMC 46355. PMID 7682714.
• Hata D, Nakamura T, Kawakami T, et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking.". Immunol. Lett. 40 (1): 65–71. doi:10.1016/0165-2478(94)90208-9. PMID 7927516.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
• Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.". J. Immunol. 158 (6): 2736–44. PMID 9058808.
• Yamanashi Y, Fukuda T, Nishizumi H, et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis.". J. Exp. Med. 185 (7): 1387–92. doi:10.1084/jem.185.7.1387. PMC 2196252. PMID 9104825.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.". J. Biol. Chem. 274 (11): 7557–64. doi:10.1074/jbc.274.11.7557. PMID 10066823.
• Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin.". Blood 93 (10): 3347–54. PMID 10233887.
• Takemoto Y, Furuta M, Sato M, et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.". Int. Immunol. 11 (12): 1957–64. doi:10.1093/intimm/11.12.1957. PMID 10590261.
• Ruzzene M, Brunati AM, Sarno S, et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.". Eur. J. Biochem. 267 (10): 3065–72. doi:10.1046/j.1432-1033.2000.01333.x. PMID 10806407.
• Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
• Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.". Biochem. J. 364 (Pt 1): 41–7. PMC 1222543. PMID 11988074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
• Uruno T, Zhang P, Liu J, et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.". Biochem. J. 371 (Pt 2): 485–93. doi:10.1042/BJ20021791. PMC 1223309. PMID 12534372.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.