HEBP1
| Heme binding protein 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HEBP1 ; HBP; HEBP | ||||||||||||
| External IDs | OMIM: 605826 HomoloGene: 8407 GeneCards: HEBP1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 50865 | 15199 | |||||||||||
| Ensembl | ENSG00000013583 | ENSMUSG00000042770 | |||||||||||
| UniProt | Q9NRV9 | Q9R257 | |||||||||||
| RefSeq (mRNA) | NM_015987 | NM_013546 | |||||||||||
| RefSeq (protein) | NP_057071 | NP_038574 | |||||||||||
| Location (UCSC) |
Chr 12: 12.97 – 13 Mb |
Chr 6: 135.14 – 135.17 Mb | |||||||||||
| PubMed search | |||||||||||||
Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.[1]
Function
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.[1]
References
Further reading
- Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA (Nov 2002). "Characterization of a human and mouse tetrapyrrole-binding protein". Archives of Biochemistry and Biophysics 407 (2): 196–201. doi:10.1016/s0003-9861(02)00471-x. PMID 12413491.
- Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I (Feb 2007). "F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor". Journal of Immunology 178 (3): 1450–6. doi:10.4049/jimmunol.178.3.1450. PMID 17237393.
- Micaelo NM, Macedo AL, Goodfellow BJ, Félix V (Nov 2010). "Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins". Journal of Molecular Graphics & Modelling 29 (3): 396–405. doi:10.1016/j.jmgm.2010.07.008. PMID 20800521.
- Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, Sozzani S, Parmentier M, Communi D (Jan 2005). "Identification and characterization of an endogenous chemotactic ligand specific for FPRL2". The Journal of Experimental Medicine 201 (1): 83–93. doi:10.1084/jem.20041277. PMC 2212760. PMID 15623572.
- Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M (Aug 2011). "Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3". Journal of Immunology 187 (3): 1475–85. doi:10.4049/jimmunol.1003545. PMID 21709160.
- Zylka MJ, Reppert SM (Dec 1999). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Research. Molecular Brain Research 74 (1-2): 175–81. doi:10.1016/s0169-328x(99)00277-6. PMID 10640688.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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