HECW1

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3L4H
Identifiers
Symbols	HECW1 ; NEDL1
External IDs	OMIM: 610384 HomoloGene: 9004 GeneCards: HECW1 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • ligase activity • ubiquitin protein ligase activity Cellular component • cytoplasm • cytosol Biological process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23072	94253
Ensembl	ENSG00000002746	ENSMUSG00000021301
UniProt	Q76N89	Q8K4P8
RefSeq (mRNA)	NM_001287059	NM_001081348
RefSeq (protein)	NP_001273988	NP_001074817
Location (UCSC)	Chr 7: 43.11 – 43.57 Mb	Chr 13: 14.23 – 14.52 Mb
PubMed search

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. ^[1]

References

1. "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1". Retrieved 2014-10-24.

Further reading

• Miyazaki, K; Fujita, T; Ozaki, T; Kato, C; Kurose, Y; Sakamoto, M; Kato, S; Goto, T; Itoyama, Y; Aoki, M; Nakagawara, A (2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". Journal of Biological Chemistry 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
• Chansard, M; Wang, J; Tran, H. C.; Neumayer, G; Shim, S. Y.; Park, Y. U.; Belzil, C; Le, H. T.; Park, S. K.; Nguyen, M. D. (2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLoS ONE 6 (1): e14583. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
• Sherva, R; Tripodis, Y; Bennett, D. A.; Chibnik, L. B.; Crane, P. K.; De Jager, P. L.; Farrer, L. A.; Saykin, A. J.; Shulman, J. M.; Naj, A; Green, R. C.; Genaroad, Consortium; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Genetics Consortium (2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
• Li, Y; Ozaki, T; Kikuchi, H; Yamamoto, H; Ohira, M; Nakagawara, A (2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
• Harvey, K. F.; Dinudom, A; Cook, D. I.; Kumar, S (2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". Journal of Biological Chemistry 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
• Zhang, L; Haraguchi, S; Koda, T; Hashimoto, K; Nakagawara, A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine and Biotechnology 2011: 831092. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
• Cui, Y; He, S; Xing, C; Lu, K; Wang, J; Xing, G; Meng, A; Jia, S; He, F; Zhang, L (2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
• Shinada, K; Tsukiyama, T; Sho, T; Okumura, F; Asaka, M; Hatakeyama, S (2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. PMID 21108931.
• Levine, D. M.; Ek, W. E.; Zhang, R; Liu, X; Onstad, L; Sather, C; Lao-Sirieix, P; Gammon, M. D.; Corley, D. A.; Shaheen, N. J.; Bird, N. C.; Hardie, L. J.; Murray, L. J.; Reid, B. J.; Chow, W. H.; Risch, H. A.; Nyrén, O; Ye, W; Liu, G; Romero, Y; Bernstein, L; Wu, A. H.; Casson, A. G.; Chanock, S. J.; Harrington, P; Caldas, I; Debiram-Beecham, I; Caldas, C; Hayward, N. K.; et al. (2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.