HELLS
| Helicase, lymphoid-specific | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HELLS ; LSH; Nbla10143; PASG; SMARCA6 | ||||||||||||
| External IDs | OMIM: 603946 MGI: 106209 HomoloGene: 50037 GeneCards: HELLS Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3070 | 15201 | |||||||||||
| Ensembl | ENSG00000119969 | ENSMUSG00000025001 | |||||||||||
| UniProt | Q9NRZ9 | Q60848 | |||||||||||
| RefSeq (mRNA) | NM_001289067 | NM_008234 | |||||||||||
| RefSeq (protein) | NP_001275996 | NP_032260 | |||||||||||
| Location (UCSC) |
Chr 10: 94.5 – 94.61 Mb |
Chr 19: 38.93 – 38.97 Mb | |||||||||||
| PubMed search | |||||||||||||
Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.[1][2][3]
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
References
- ↑ Geiman TM, Durum SK, Muegge K (Feb 1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)". Genomics 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
- ↑ Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res 60 (13): 3612–22. PMID 10910076.
- 1 2 "Entrez Gene: HELLS helicase, lymphoid-specific".
Further reading
- Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sun LQ, Lee DW, Zhang Q, et al. (2004). "Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG". Genes Dev. 18 (9): 1035–46. doi:10.1101/gad.1176104. PMC 406293. PMID 15105378.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Yano M, Ouchida M, Shigematsu H, et al. (2004). "Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer". Int. J. Cancer 112 (1): 8–13. doi:10.1002/ijc.20407. PMID 15305370.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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