HERV-FRD

Endogenous retrovirus group FRD, member 1
PDB rendering based on 1y4m.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Y4M​
Identifiers
Symbols	ERVFRD-1 ; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; UNQ6191; envFRD
External IDs	OMIM: 610524 MGI: 3045308 HomoloGene: 86779 GeneCards: ERVFRD-1 Gene
Gene ontology Molecular function • structural molecule activity Cellular component • plasma membrane • integral component of membrane • viral envelope Biological process • syncytium formation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	405754	239167
Ensembl	ENSG00000244476	ENSMUSG00000047977
UniProt	P60508	Q8BI41
RefSeq (mRNA)	NM_207582	NM_173420
RefSeq (protein)	NP_997465	NP_775596
Location (UCSC)	Chr 6: 11.1 – 11.11 Mb	Chr 14: 69.29 – 69.29 Mb
PubMed search

HERV-FRD provirus ancestral Env polyprotein, also known as HERV-FRD, is a human gene.^[1]

References

1. "Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• de Parseval N, Lazar V, Casella JF, et al. (2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.". J. Virol. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Blaise S, de Parseval N, Bénit L, Heidmann T (2004). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Blaise S, Ruggieri A, Dewannieux M, et al. (2004). "Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians.". J. Virol. 78 (2): 1050–4. doi:10.1128/JVI.78.2.1050-1054.2004. PMC 368808. PMID 14694139.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Renard M, Varela PF, Letzelter C, et al. (2005). "Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.". J. Mol. Biol. 352 (5): 1029–34. doi:10.1016/j.jmb.2005.07.058. PMID 16140326.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Malassiné A, Blaise S, Handschuh K, et al. (2007). "Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells.". Placenta 28 (2-3): 185–91. doi:10.1016/j.placenta.2006.03.001. PMID 16714059.