HES3

Hes family bHLH transcription factor 3
Identifiers
Symbols	HES3 ; bHLHb43
External IDs	OMIM: 609971 HomoloGene: 7358 GeneCards: HES3 Gene
Gene ontology Molecular function • DNA binding • transcription factor binding • protein dimerization activity Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • in utero embryonic development • transcription, DNA-templated • midbrain-hindbrain boundary morphogenesis • oculomotor nerve development • trochlear nerve development • hindbrain morphogenesis • midbrain development • positive regulation of transcription from RNA polymerase II promoter • regulation of timing of neuron differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390992	15207
Ensembl	ENSG00000173673	ENSMUSG00000028946
UniProt	Q5TGS1	Q61657
RefSeq (mRNA)	NM_001024598	NM_008237
RefSeq (protein)	NP_001019769	NP_032263
Location (UCSC)	Chr 1: 6.24 – 6.25 Mb	Chr 4: 152.29 – 152.29 Mb
PubMed search

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene. ^[1]

References

1. "Entrez Gene: Hes family bHLH transcription factor 3". Retrieved 2014-09-11.

Further reading

• Katoh, M; Katoh, M (2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International journal of oncology 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh, M; Katoh, M (2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International journal of oncology 31 (2): 461–6. PMID 17611704.
• Fukami, M; Wada, Y; Okada, M; Kato, F; Katsumata, N; Baba, T; Morohashi, K; Laporte, J; Kitagawa, M; Ogata, T (2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". Journal of Biological Chemistry 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
• Park, D. M.; Jung, J; Masjkur, J; Makrogkikas, S; Ebermann, D; Saha, S; Rogliano, R; Paolillo, N; Pacioni, S; McKay, R. D.; Poser, S; Androutsellis-Theotokis, A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports 3: 1095. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.