HHIP

Hedgehog interacting protein
Rendering based on PDB 2WFT​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2WFT​, 2WFX​, 2WG3​, 2WG4​, 3HO3​, 3HO4​, 3HO5​
Identifiers
Symbols	HHIP ; HIP
External IDs	OMIM: 606178 MGI: 1341847 HomoloGene: 32469 GeneCards: HHIP Gene
Gene ontology Molecular function • protein binding • zinc ion binding • oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor • quinone binding • hedgehog family protein binding Cellular component • extracellular region • cytoplasm • integral component of plasma membrane • cell surface • ciliary membrane Biological process • carbohydrate metabolic process • smoothened signaling pathway • neuroblast proliferation • dorsal/ventral pattern formation • negative regulation of signal transduction • regulation of fibroblast growth factor receptor signaling pathway • negative regulation of smoothened signaling pathway • skeletal system morphogenesis • oxidation-reduction process • epithelial tube branching involved in lung morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64399	15245
Ensembl	ENSG00000164161	ENSMUSG00000064325
UniProt	Q96QV1	Q7TN16
RefSeq (mRNA)	NM_022475	NM_020259
RefSeq (protein)	NP_071920	NP_064655
Location (UCSC)	Chr 4: 144.65 – 144.75 Mb	Chr 8: 79.97 – 80.06 Mb
PubMed search

Hedgehog interacting protein is a protein that in humans is encoded by the HHIP gene.^[1][2][3]

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.^[3]

References

1. Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703.
2. Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473.
3. "Entrez Gene: HHIP hedgehog interacting protein".

Further reading

• Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature 397 (6720): 617–21. doi:10.1038/17611. PMID 10050855.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Olsen CL, Hsu PP, Glienke J, et al. (2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors". BMC Cancer 4: 43. doi:10.1186/1471-2407-4-43. PMC 512291. PMID 15294024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kayed H, Kleeff J, Esposito I, et al. (2005). "Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas". Mol. Carcinog. 42 (4): 183–92. doi:10.1002/mc.20088. PMID 15754313.
• Martin ST, Sato N, Dhara S, et al. (2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther. 4 (7): 728–33. doi:10.4161/cbt.4.7.1802. PMID 15970691.