HIST1H2BF

Histone cluster 1, H2bf
PDB rendering based on 1aoi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3A6N​, 3AFA​, 3AN2​, 3AV1​, 3AV2​, 3AYW​, 3AZE​, 3AZF​, 3AZG​, 3AZH​, 3AZI​, 3AZJ​, 3AZK​, 3AZL​, 3AZM​, 3AZN​
Identifiers
Symbols	HIST1H2BF ; H2B/g; H2BFG
External IDs	OMIM: 602804 MGI: 1915274 HomoloGene: 136358 GeneCards: HIST1H2BF Gene
Gene ontology Molecular function • DNA binding • protein binding • protein heterodimerization activity Cellular component • nucleosome • nuclear nucleosome • extracellular space • nucleus • nucleoplasm • extracellular exosome Biological process • innate immune response in mucosa • chromatin organization • nucleosome assembly • antibacterial humoral response • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8343	319179
Ensembl	ENSG00000277224	ENSMUSG00000018102
UniProt	P62807	Q6ZWY9
RefSeq (mRNA)	NM_003522	NM_001177653
RefSeq (protein)	NP_003513	NP_001171124
Location (UCSC)	Chr 6: 26.2 – 26.2 Mb	Chr 13: 23.57 – 23.57 Mb
PubMed search

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BF gene.^[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[3]

References

1. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
3. "Entrez Gene: HIST1H2BF histone cluster 1, H2bf".

Further reading

• Ohe Y, Hayashi H, Iwai K (1979). "Human spleen histone H2B. Isolation and amino acid sequence". J. Biochem. 85 (2): 615–24. PMID 422550.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633. PMID 9566873.
• Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.