HIST1H2BJ

Histone cluster 1, H2bj
PDB rendering based on 1aoi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3A6N​, 3AFA​, 3AN2​, 3AV1​, 3AV2​, 3AYW​, 3AZE​, 3AZF​, 3AZG​, 3AZH​, 3AZI​, 3AZJ​, 3AZK​, 3AZL​, 3AZM​, 3AZN​, 3W96​, 3W97​, 3W98​, 3W99​, 3WA9​, 3WAA​, 3WTP​, 4CAY​
Identifiers
Symbols	HIST1H2BJ ; H2B/r; H2BFR; H2BJ
External IDs	OMIM: 615044 HomoloGene: 128594 GeneCards: HIST1H2BJ Gene
Gene ontology Molecular function • DNA binding • protein heterodimerization activity Cellular component • nucleosome • nuclear nucleosome • extracellular space • nucleus • nucleoplasm Biological process • innate immune response in mucosa • chromatin organization • nucleosome assembly • antibacterial humoral response • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8970	319190
Ensembl	ENSG00000124635	ENSMUSG00000068854
UniProt	P06899	Q64524
RefSeq (mRNA)	NM_021058	NM_178214
RefSeq (protein)	NP_066402	NP_835586
Location (UCSC)	Chr 6: 27.13 – 27.13 Mb	Chr 3: 96.22 – 96.22 Mb
PubMed search

Histone H2B type 1-J is a protein that in humans is encoded by the HIST1H2BJ gene.^[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.^[3]

References

1. Zhong R, Roeder RG, Heintz N (Jan 1984). "The primary structure and expression of four cloned human histone genes". Nucleic Acids Res 11 (21): 7409–7425. doi:10.1093/nar/11.21.7409. PMC 326492. PMID 6647026.
2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
3. "Entrez Gene: HIST1H2BJ histone cluster 1, H2bj".

Further reading

• Alnemri ES, Litwack G (1989). "Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease". J. Biol. Chem. 264 (7): 4104–11. PMID 2917990.
• Frohm M, Gunne H, Bergman AC, et al. (1996). "Biochemical and antibacterial analysis of human wound and blister fluid". Eur. J. Biochem. 237 (1): 86–92. doi:10.1111/j.1432-1033.1996.0086n.x. PMID 8620898.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633. PMID 9566873.
• Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132.
• Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome 10 (7): 768–770. doi:10.1007/s003359901089. PMID 10384058.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
• Galasinski SC, Louie DF, Gloor KK, et al. (2002). "Global regulation of post-translational modifications on core histones". J. Biol. Chem. 277 (4): 2579–2588. doi:10.1074/jbc.M107894200. PMID 11709551.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–244. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Kim HS, Cho JH, Park HW, et al. (2002). "Endotoxin-neutralizing antimicrobial proteins of the human placenta". J. Immunol. 168 (5): 2356–64. doi:10.4049/jimmunol.168.5.2356. PMID 11859126.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Giampuzzi M, Oleggini R, Di Donato A (2003). "Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved". Biochim. Biophys. Acta 1647 (1–2): 245–51. doi:10.1016/s1570-9639(03)00059-1. PMID 12686141.
• Cheung WL, Ajiro K, Samejima K, et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell 113 (4): 507–517. doi:10.1016/S0092-8674(03)00355-6. PMID 12757711.
• Tollin M, Bergman P, Svenberg T, et al. (2004). "Antimicrobial peptides in the first line defence of human colon mucosa". Peptides 24 (4): 523–530. doi:10.1016/S0196-9781(03)00114-1. PMID 12860195.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Howell SJ, Wilk D, Yadav SP, Bevins CL (2004). "Antimicrobial polypeptides of the human colonic epithelium". Peptides 24 (11): 1763–1770. doi:10.1016/j.peptides.2003.07.028. PMID 15019208.