HIST1H2BM

Histone cluster 1, H2bm

PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BM ; H2B/e; H2BFE; dJ160A22.3
External IDs OMIM: 602802 HomoloGene: 136772 GeneCards: HIST1H2BM Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8342 319187
Ensembl ENSG00000273703 ENSMUSG00000095217
UniProt Q99879 P10853
RefSeq (mRNA) NM_003521 NM_178201
RefSeq (protein) NP_003512 NP_835508
Location (UCSC) Chr 6:
27.82 – 27.82 Mb
Chr 13:
21.75 – 21.75 Mb
PubMed search

Histone H2B type 1-M is a protein that in humans is encoded by the HIST1H2BM gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]

References

  1. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  3. 1 2 "Entrez Gene: HIST1H2BM histone cluster 1, H2bm".

Further reading

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