HIST1H4J

Histone cluster 1, H4j
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZKK, 2BQZ, 2CV5, 2IG0, 2KWN, 2KWO, 2LVM, 2QQS, 2RJE, 2RNY, 2RS9, 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN, 3CFS, 3CFV, 3F9W, 3F9X, 3F9Y, 3F9Z, 3IJ1, 3JPX, 3NQJ, 3NQU, 3O36, 3QBY, 3QZS, 3QZT, 3QZV, 3R45, 3UVW, 3UVX, 3UVY, 3UW9, 3W96, 3W97, 3W98, 3W99, 3WA9, 3WAA, 3WKJ, 3WTP, 4GQB, 4H9N, 4H9O, 4H9P, 4H9Q, 4H9R, 4H9S, 4HGA, 4M38, 4N3W, 4N4F, 4QUT, 4QUU, 4QYD
Identifiers
Symbols	HIST1H4J ; H4/e; H4F2iv; H4FE; dJ160A22.2
External IDs	OMIM: 602826 HomoloGene: 134492 GeneCards: HIST1H4J Gene
Gene ontology Molecular function • DNA binding • protein binding • histone demethylase activity (H4-K20 specific) • histone binding • poly(A) RNA binding • protein heterodimerization activity Cellular component • nuclear chromosome • nucleosome • extracellular region • nucleus • nucleoplasm • membrane • protein complex • extracellular exosome Biological process • chromatin silencing at rDNA • mitotic cell cycle • telomere maintenance • chromatin organization • nucleosome assembly • DNA replication-dependent nucleosome assembly • DNA replication-independent nucleosome assembly • small GTPase mediated signal transduction • gene expression • DNA methylation on cytosine • CENP-A containing nucleosome assembly • histone H4-K20 demethylation • regulation of gene expression, epigenetic • negative regulation of megakaryocyte differentiation • negative regulation of gene expression, epigenetic • protein heterotetramerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8363	319157
Ensembl	ENSG00000197238	ENSMUSG00000069274
UniProt	P62805	P62806
RefSeq (mRNA)	NM_021968	NM_175655
RefSeq (protein)	NP_068803	NP_783586
Location (UCSC)	Chr 6: 27.82 – 27.82 Mb	Chr 13: 23.55 – 23.55 Mb
PubMed search

Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene.^[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].^[1]

References

1. "Entrez Gene: Histone cluster 1, H4j". Retrieved 2012-03-12.

Further reading

• Deng, L.; De La Fuente, C.; Fu, P.; Wang, L.; Donnelly, R.; Wade, J. D.; Lambert, P.; Li, H.; Lee, C. G.; Kashanchi, F. (2000). "Acetylation of HIV-1 Tat by CBP/P300 Increases Transcription of Integrated HIV-1 Genome and Enhances Binding to Core Histones". Virology 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng, L.; Wang, D.; De La Fuente, C.; Wang, L.; Li, H.; Lee, C. G.; Donnelly, R.; Wade, J. D.; Lambert, P.; Kashanchi, F. (2001). "Enhancement of the p300 HAT Activity by HIV-1 Tat on Chromatin DNA". Virology 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
• Marzluff, W. F.; Gongidi, P.; Woods, K. R.; Jin, J.; Maltais, L. J. (2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
• Lusic, M.; Marcello, A.; Cereseto, A.; Giacca, M. (2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Heintz, N.; Zernik, M.; Roeder, R. G. (1981). "The structure of the human histone genes: Clustered but not tandemly repeated". Cell 24 (3): 661–668. doi:10.1016/0092-8674(81)90092-1. PMID 6265100.
• Albig, W.; Doenecke, D. (1997). "The human histone gene cluster at the D6S105 locus". Human Genetics 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
• El Kharroubi, A.; Piras, G.; Zensen, R.; Martin, M. A. (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology 18 (5): 2535–2544. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.