HIST1H4K

Histone cluster 1, H4k

PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H4K ; H4/d; H4F2iii; H4FD; dJ160A22.1
External IDs OMIM: 602825 MGI: 2448423 HomoloGene: 134474 GeneCards: HIST1H4K Gene
Orthologs
Species Human Mouse
Entrez 8362 319159
Ensembl ENSG00000273542 ENSMUSG00000067455
UniProt P62805 P62806
RefSeq (mRNA) NM_003541 NM_178210
RefSeq (protein) NP_003532 NP_835582
Location (UCSC) Chr 6:
27.83 – 27.83 Mb
Chr 13:
21.74 – 21.74 Mb
PubMed search

Histone H4 is a protein that in humans is encoded by the HIST1H4K gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]

References

  1. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  2. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  3. 1 2 "Entrez Gene: HIST1H4K histone cluster 1, H4k".

Further reading

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