HMG20B

High mobility group 20B
PDB rendering based on 2crj.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2crj​
Identifiers
Symbols	HMG20B ; BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
External IDs	OMIM: 605535 MGI: 1341190 HomoloGene: 74949 GeneCards: HMG20B Gene
Gene ontology Molecular function • DNA binding • chromatin binding • protein binding • protein heterodimerization activity Cellular component • nucleoplasm • chromosome Biological process • chromatin organization • chromatin remodeling • transcription, DNA-templated • regulation of transcription, DNA-templated • cell cycle • blood coagulation • negative regulation of protein sumoylation • skeletal muscle cell differentiation • positive regulation of neuron differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10362	15353
Ensembl	ENSG00000064961	ENSMUSG00000020232
UniProt	Q9P0W2	Q9Z104
RefSeq (mRNA)	NM_006339	NM_001163165
RefSeq (protein)	NP_006330	NP_001156637
Location (UCSC)	Chr 19: 3.57 – 3.58 Mb	Chr 10: 81.35 – 81.35 Mb
PubMed search

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.^[1][2]

Interactions

HMG20B has been shown to interact with KIF4A,^[3] HDAC1,^[4] Histone deacetylase 2,^[4][5] PHF21A,^[4][6] RCOR1^[4] and BRCA2.^[4][7]

References

1. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacos M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenet Cell Genet 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667.
2. "Entrez Gene: HMG20B high-mobility group 20B".
3. Lee, Young Mi; Kim Wankee (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". Biochem. J. (England) 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
4. Hakimi, Mohamed-Ali; Bochar Daniel A; Chenoweth Josh; Lane William S; Mandel Gail; Shiekhattar Ramin (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7420–5. doi:10.1073/pnas.112008599. ISSN 0027-8424. PMC 124246. PMID 12032298.
5. Hakimi, Mohamed-Ali; Dong Yuanshu; Lane William S; Speicher David W; Shiekhattar Ramin (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763.
6. Iwase, Shigeki; Januma Aya; Miyamoto Kiyoko; Shono Naomi; Honda Arata; Yanagisawa Junn; Baba Tadashi (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. (United States) 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. ISSN 0006-291X. PMID 15325272.
7. Marmorstein, L Y; Kinev A V; Chan G K; Bochar D A; Beniya H; Epstein J A; Yen T J; Shiekhattar R (Jan 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell (United States) 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. ISSN 0092-8674. PMID 11207365.

Further reading

• Wattler F, Wattler S, Kelly M, et al. (1999). "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family". Genomics 60 (2): 172–8. doi:10.1006/geno.1999.5913. PMID 10486208.
• Marmorstein LY, Kinev AV, Chan GK, et al. (2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365.
• Lee YM, Shin H, Choi W, et al. (2002). "Characterization of human SMARCE1r high-mobility-group protein". Biochim. Biophys. Acta 1574 (3): 269–76. doi:10.1016/s0167-4781(01)00373-6. PMID 11997092.
• Hakimi MA, Bochar DA, Chenoweth J, et al. (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
• Wang C, McCarty IM, Balazs L, et al. (2002). "Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35". Biochem. Biophys. Res. Commun. 295 (1): 129–35. doi:10.1016/S0006-291X(02)00624-1. PMID 12083779.
• Wang C, McCarty IM, Balazs L, et al. (2002). "Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens". Biochem. Biophys. Res. Commun. 295 (1): 136–41. doi:10.1016/S0006-291X(02)00625-3. PMID 12083780.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
• Lee YM, Kim W (2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". Biochem. J. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Iwase S, Januma A, Miyamoto K, et al. (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• HMG20B human gene location in the UCSC Genome Browser.
• HMG20B human gene details in the UCSC Genome Browser.