HNRNPLL
| Heterogeneous nuclear ribonucleoprotein L-like | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HNRNPLL ; HNRPLL; SRRF | ||||||||||||
| External IDs | OMIM: 611208 HomoloGene: 26701 GeneCards: HNRNPLL Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 92906 | 72692 | |||||||||||
| Ensembl | ENSG00000143889 | ENSMUSG00000024095 | |||||||||||
| UniProt | Q8WVV9 | Q921F4 | |||||||||||
| RefSeq (mRNA) | NM_001142650 | NM_144802 | |||||||||||
| RefSeq (protein) | NP_001136122 | NP_659051 | |||||||||||
| Location (UCSC) |
Chr 2: 38.56 – 38.6 Mb |
Chr 17: 80.03 – 80.06 Mb | |||||||||||
| PubMed search | |||||||||||||
Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene. [1]
Function
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].
References
- ↑ "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like". Retrieved 2014-01-24.
Further reading
- Lai, Y.; Song, M.; Hakala, K.; Weintraub, S. T.; Shiio, Y. (2011). "Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome". Journal of Proteome Research 10 (11): 5175–5182. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
- Topp, J. D.; Jackson, J.; Melton, A. A.; Lynch, K. W. (2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA 14 (10): 2038–2049. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
- Wu, Z.; Yates, A. L.; Hoyne, G. F.; Goodnow, C. C. (2010). "Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation". The Journal of Immunology 185 (1): 231–238. doi:10.4049/jimmunol.0903625. PMID 20505149.
- Oberdoerffer, S.; Moita, L. F.; Neems, D.; Freitas, R. P.; Hacohen, N.; Rao, A. (2008). "Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL". Science 321 (5889): 686–691. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.
- Fedorova, O. A.; Moiseeva, T. N.; Nikiforov, A. A.; Tsimokha, A. S.; Livinskaya, V. A.; Hodson, M.; Bottrill, A.; Evteeva, I. N.; Ermolayeva, J. B.; Kuznetzova, I. M.; Turoverov, K. K.; Eperon, I.; Barlev, N. A. (2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications 416 (3–4): 258–265. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
- Shur, I.; Ben-Avraham, D.; Benayahu, D. (2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene 334: 113–121. doi:10.1016/j.gene.2004.03.012. PMID 15256261.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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