HNRPA2B1

Heterogeneous nuclear ribonucleoprotein A2/B1
PDB rendering based on 1x4b.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X4B​
Identifiers
Symbols	HNRNPA2B1 ; HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1
External IDs	OMIM: 600124 MGI: 104819 HomoloGene: 22992 GeneCards: HNRNPA2B1 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • protein binding • single-stranded telomeric DNA binding • poly(A) RNA binding • pre-mRNA intronic binding Cellular component • nucleus • nucleoplasm • spliceosomal complex • cytoplasm • membrane • ribonucleoprotein complex • catalytic step 2 spliceosome Biological process • negative regulation of transcription from RNA polymerase II promoter • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • gene expression • negative regulation of mRNA splicing, via spliceosome • RNA transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3181	53379
Ensembl	ENSG00000122566	ENSMUSG00000004980
UniProt	P22626	O88569
RefSeq (mRNA)	NM_002137	NM_016806
RefSeq (protein)	NP_002128	NP_058086
Location (UCSC)	Chr 7: 26.19 – 26.2 Mb	Chr 6: 51.46 – 51.47 Mb
PubMed search

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.^[1]

Function

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.^[2] HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.

Interactions

HNRPA2B1 has been shown to interact with Casein kinase 2, alpha 1.^[3]

References

1. Biamonti G, Ruggiu M, Saccone S, Della Valle G, Riva S (Aug 1994). "Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1". Nucleic Acids Res. 22 (11): 1996–2002. doi:10.1093/nar/22.11.1996. PMC 308112. PMID 8029005.
2. "Entrez Gene: HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1".
3. Pancetti F, Bosser R, Krehan A, Pyerin W, Itarte E, Bachs O (Jun 1999). "Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2". Biochem. Biophys. Res. Commun. 260 (1): 17–22. doi:10.1006/bbrc.1999.0849. PMID 10381337.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Bauw G, Rasmussen HH, van den Bulcke M, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (1990). "Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes". Electrophoresis 11 (7): 528–36. doi:10.1002/elps.1150110703. PMID 1699755.
• Wilk HE, Schaefer KP, Agris PF, Boak AM, Kovacs SA (1991). "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA". Mol. Cell. Biochem. 106 (1): 55–66. doi:10.1007/BF00231189. PMID 1833625.
• Burd CG, Swanson MS, Görlach M, Dreyfuss G (1989). "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9788–92. doi:10.1073/pnas.86.24.9788. PMC 298587. PMID 2557628.
• Kumar A, Williams KR, Szer W (1986). "Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins". J. Biol. Chem. 261 (24): 11266–73. PMID 3733753.
• Faura M, Renau-Piqueras J, Bachs O, Bosser R (1995). "Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues". Biochem. Biophys. Res. Commun. 217 (2): 554–60. doi:10.1006/bbrc.1995.2811. PMID 7503735.
• Kozu T, Henrich B, Schäfer KP (1995). "Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1". Genomics 25 (2): 365–71. doi:10.1016/0888-7543(95)80035-K. PMID 7789969.
• Van Laer L, Van Camp G, Green ED, Huizing EH, Willems PJ (1997). "Physical mapping of the HOXA1 gene and the hnRPA2B1 gene in a YAC contig from human chromosome 7p14-p15". Hum. Genet. 99 (6): 831–3. doi:10.1007/s004390050457. PMID 9187682.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Montuenga LM, Zhou J, Avis I, Vos M, Martinez A, Cuttitta F, Treston AM, Sunday M, Mulshine JL (1998). "Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development". Am. J. Respir. Cell Mol. Biol. 19 (4): 554–62. doi:10.1165/ajrcmb.19.4.3185. PMID 9761751.
• Pancetti F, Bosser R, Krehan A, Pyerin W, Itarte E, Bachs O (1999). "Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2". Biochem. Biophys. Res. Commun. 260 (1): 17–22. doi:10.1006/bbrc.1999.0849. PMID 10381337.
• Hamilton BJ, Nichols RC, Tsukamoto H, Boado RJ, Pardridge WM, Rigby WF (1999). "hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo". Biochem. Biophys. Res. Commun. 261 (3): 646–51. doi:10.1006/bbrc.1999.1040. PMID 10441480.
• Nichols RC, Wang XW, Tang J, Hamilton BJ, High FA, Herschman HR, Rigby WF (2000). "The RGG domain in hnRNP A2 affects subcellular localization". Exp. Cell Res. 256 (2): 522–32. doi:10.1006/excr.2000.4827. PMID 10772824.
• Matsui M, Horiguchi H, Kamma H, Fujiwara M, Ohtsubo R, Ogata T (2000). "Testis- and developmental stage-specific expression of hnRNP A2/B1 splicing isoforms, B0a/b". Biochim. Biophys. Acta 1493 (1-2): 33–40. doi:10.1016/s0167-4781(00)00154-8. PMID 10978504.
• Zhou J, Allred DC, Avis I, Martínez A, Vos MD, Smith L, Treston AM, Mulshine JL (2001). "Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer". Breast Cancer Res. Treat. 66 (3): 217–24. doi:10.1023/A:1010631915831. PMID 11510693.
• Pioli PA, Rigby WF (2001). "The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression". J. Biol. Chem. 276 (43): 40346–52. doi:10.1074/jbc.M105391200. PMID 11517223.
• Kim SH, Dierssen M, Ferreres JC, Fountoulakis M, Lubec G (2001). "Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains". J. Neural Transm. Suppl. (61): 273–80. doi:10.1007/978-3-7091-6262-0_22. PMID 11771750.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.