HNT

Neurotrimin
Identifiers
Symbols	NTM ; HNT; IGLON2; NTRI
External IDs	OMIM: 607938 MGI: 2446259 HomoloGene: 41139 GeneCards: NTM Gene
Gene ontology Molecular function • protein binding Cellular component • plasma membrane • cell-cell junction • cell surface • anchored component of membrane • neuron projection • neuronal cell body Biological process • cell adhesion • neuron recognition • single organismal cell-cell adhesion • regulation of neurogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50863	235106
Ensembl	ENSG00000182667	ENSMUSG00000059974
UniProt	Q9P121	Q8BG33
RefSeq (mRNA)	NM_001048209	NM_172290
RefSeq (protein)	NP_001041674	NP_758494
Location (UCSC)	Chr 11: 131.37 – 132.34 Mb	Chr 9: 28.99 – 29.96 Mb
PubMed search

Neurotrimin is a protein that in humans is encoded by the NTM gene.^[1][2]

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.^[2]

References

1. Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci 15 (3 Pt 2): 2141–56. PMID 7891157.
2. "Entrez Gene: HNT neurotrimin".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene.". Sci. China, C, Life Sci. 47 (2): 158–64. doi:10.1360/03yc0072. PMID 15379248.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.