HOMER3

Homer scaffolding protein 3
Rendering based on PDB 2P8V​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2P8V​, 3CVF​
Identifiers
Symbols	HOMER3 ; HOMER-3; VESL3
External IDs	OMIM: 604800 MGI: 1347359 HomoloGene: 37972 GeneCards: HOMER3 Gene
Gene ontology Molecular function • protein binding • protein C-terminus binding • protein domain specific binding • G-protein coupled glutamate receptor binding Cellular component • cellular_component • cytoplasm • cytosol • plasma membrane • cell junction • basal part of cell • postsynaptic membrane • neuronal postsynaptic density Biological process • protein targeting • G-protein coupled glutamate receptor signaling pathway • regulation of store-operated calcium entry Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9454	26558
Ensembl	ENSG00000051128	ENSMUSG00000003573
UniProt	Q9NSC5	Q99JP6
RefSeq (mRNA)	NM_001145721	NM_001146153
RefSeq (protein)	NP_001139193	NP_001139625
Location (UCSC)	Chr 19: 18.93 – 18.94 Mb	Chr 8: 70.28 – 70.29 Mb
PubMed search

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.^[1][2][3]

Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.^[3]

Interactions

HOMER3 has been shown to interact with TRPC1^[4] and RYR1.^[5]

See also

• HOMER1
• HOMER2

References

1. Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
2. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
3. "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
4. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576.
5. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.

Further reading

• Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF (Mar 1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.
• Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Oct 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
• Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
• Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576.
• Ishiguro K, Xavier R (Mar 2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain". Blood 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
• Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genetics 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
• Schreiner D, Müller K, Hofer HW (Oct 2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Letters 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.