HOOK2

Hook microtubule-tethering protein 2
Identifiers
Symbols	HOOK2 ; HK2
External IDs	OMIM: 607824 MGI: 2181664 HomoloGene: 8332 GeneCards: HOOK2 Gene
Gene ontology Molecular function • protein binding • identical protein binding Cellular component • centrosome • microtubule • HOPS complex • FHF complex Biological process • endocytosis • endosome organization • lysosome organization • endosome to lysosome transport • protein transport • early endosome to late endosome transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29911	170833
Ensembl	ENSG00000095066	ENSMUSG00000052566
UniProt	Q96ED9	Q7TMK6
RefSeq (mRNA)	NM_001100176	NM_001167991
RefSeq (protein)	NP_001093646	NP_001161463
Location (UCSC)	Chr 19: 12.76 – 12.87 Mb	Chr 8: 84.99 – 85 Mb
PubMed search

Protein Hook homolog 2 (HK2) is a protein^[1] that in humans is encoded by the HOOK2 gene.^[2][3]

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.^[3]

References

1. Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics 151 (2): 675–84. PMC 1460498. PMID 9927460.
2. Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
3. "Entrez Gene: hook homolog 2 (Drosophila)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.". Mol. Biol. Cell 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC 2592673. PMID 18799622.
• Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome.". Mol. Biol. Cell 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC 2777108. PMID 19793914.
• Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation.". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156. PMID 17540036.
• Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.". Traffic 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.