HOXA6
| Homeobox A6 | |||||||||||||
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PDB rendering based on 1ahd. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HOXA6 ; HOX1; HOX1.2; HOX1B | ||||||||||||
| External IDs | OMIM: 142951 MGI: 96178 HomoloGene: 7765 GeneCards: HOXA6 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3203 | 15403 | |||||||||||
| Ensembl | ENSG00000106006 | ENSMUSG00000043219 | |||||||||||
| UniProt | P31267 | P09092 | |||||||||||
| RefSeq (mRNA) | NM_024014 | NM_010454 | |||||||||||
| RefSeq (protein) | NP_076919 | NP_034584 | |||||||||||
| Location (UCSC) |
Chr 7: 27.15 – 27.15 Mb |
Chr 6: 52.21 – 52.21 Mb | |||||||||||
| PubMed search | |||||||||||||
Homeobox protein Hox-A6 is a protein that in humans is encoded by the HOXA6 gene.[1][2][3]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[3]
References
- ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- 1 2 "Entrez Gene: HOXA6 homeobox A6".
Further reading
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
- Walters JR, Howard A, Rumble HE, et al. (1997). "Differences in expression of homeobox transcription factors in proximal and distal human small intestine". Gastroenterology 113 (2): 472–7. doi:10.1053/gast.1997.v113.pm9247466. PMID 9247466.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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