HRC (gene)

Histidine rich calcium binding protein
Identifiers
Symbols	HRC ; MGC133236
External IDs	OMIM: 142705 MGI: 96226 HomoloGene: 135866 GeneCards: HRC Gene
Gene ontology Molecular function • calcium ion binding • protein binding • ion channel binding • ATPase binding Cellular component • cytosol • Z disc • sarcoplasmic reticulum membrane • sarcoplasmic reticulum lumen Biological process • regulation of heart rate • muscle contraction • positive regulation of heart rate • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of peptidyl-serine phosphorylation • positive regulation of heart contraction • cytosolic calcium ion homeostasis • regulation of ryanodine-sensitive calcium-release channel activity • regulation of cell communication by electrical coupling involved in cardiac conduction • positive regulation of relaxation of cardiac muscle • regulation of calcium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3270	15464
Ensembl	ENSG00000130528	ENSMUSG00000038239
UniProt	P23327	E9Q399
RefSeq (mRNA)	NM_002152	NM_010473
RefSeq (protein)	NP_002143	NP_034603
Location (UCSC)	Chr 19: 49.15 – 49.16 Mb	Chr 7: 45.34 – 45.34 Mb
PubMed search

Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene.^[1][2]

Function

Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity^[2]

References

1. Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
2. "Entrez Gene: HRC histidine rich calcium binding protein".

Further reading

• Anderson NL, Anderson NG (Nov 2002). "The human plasma proteome: history, character, and diagnostic prospects". Molecular & Cellular Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
• Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL (May 1989). "Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins". The Journal of Biological Chemistry 264 (14): 8260–70. PMID 2498310.
• Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS (Aug 1999). "Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein". FEBS Letters 456 (3): 399–402. doi:10.1016/S0014-5793(99)00993-X. PMID 10462052.
• Lee HG, Kang H, Kim DH, Park WJ (Oct 2001). "Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum". The Journal of Biological Chemistry 276 (43): 39533–8. doi:10.1074/jbc.M010664200. PMID 11504710.
• Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A (Dec 2001). "Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region". Biochemical and Biophysical Research Communications 289 (5): 1125–34. doi:10.1006/bbrc.2001.6126. PMID 11741309.
• Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ (Jan 2003). "Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein)". Biochemical and Biophysical Research Communications 300 (1): 192–6. doi:10.1016/S0006-291X(02)02829-2. PMID 12480542.
• Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL (May 2004). "HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo". Molecular and Cellular Biology 24 (9): 3757–68. doi:10.1128/MCB.24.9.3757-3768.2004. PMC 387749. PMID 15082771.
• Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (Oct 2004). "Regulation of myocardial function by histidine-rich, calcium-binding protein". American Journal of Physiology. Heart and Circulatory Physiology 287 (4): H1705–11. doi:10.1152/ajpheart.01211.2003. PMID 15191886.
• Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG (Sep 2007). "Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase". American Journal of Physiology. Heart and Circulatory Physiology 293 (3): H1581–9. doi:10.1152/ajpheart.00278.2007. PMID 17526652.