HS3ST2

Heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Identifiers
Symbols	HS3ST2 ; 30ST2; 3OST2
External IDs	OMIM: 604056 MGI: 1333802 HomoloGene: 21220 GeneCards: HS3ST2 Gene
EC number	2.8.2.29
Gene ontology Molecular function • sulfotransferase activity • [heparan sulfate-glucosamine 3-sulfotransferase 2 activity] Cellular component • Golgi membrane • integral component of membrane Biological process • carbohydrate metabolic process • glycosaminoglycan biosynthetic process • circadian rhythm • glycosaminoglycan metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9956	195646
Ensembl	ENSG00000122254	ENSMUSG00000046321
UniProt	Q9Y278	Q673U1
RefSeq (mRNA)	NM_006043	NM_001081327
RefSeq (protein)	NP_006034	NP_001074796
Location (UCSC)	Chr 16: 22.81 – 22.92 Mb	Chr 7: 121.39 – 121.5 Mb
PubMed search

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.^[1][2]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.^[2]

References

1. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
2. "Entrez Gene: HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2".

Further reading

• Lawrence R, Yabe T, Hajmohammadi S, et al. (2007). "The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.". Matrix Biol. 26 (6): 442–55. doi:10.1016/j.matbio.2007.03.002. PMC 1993827. PMID 17482450.
• O'Donnell CD, Tiwari V, Oh MJ, Shukla D (2006). "A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.". Virology 346 (2): 452–9. doi:10.1016/j.virol.2005.11.003. PMID 16336986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Miyamoto K, Asada K, Fukutomi T, et al. (2003). "Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.". Oncogene 22 (2): 274–80. doi:10.1038/sj.onc.1206146. PMID 12527896.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu J, Shworak NW, Sinaÿ P, et al. (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.". J. Biol. Chem. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
• Razi N, Lindahl U (1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.". J. Biol. Chem. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.