HSD17B2

Hydroxysteroid (17-beta) dehydrogenase 2
Identifiers
Symbols	HSD17B2 ; EDH17B2; HSD17; SDR9C2
External IDs	OMIM: 109685 MGI: 1096386 HomoloGene: 99709 ChEMBL: 2789 GeneCards: HSD17B2 Gene
EC number	1.1.1.239, 1.1.1.62
Gene ontology Molecular function • estradiol 17-beta-dehydrogenase activity • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity • testosterone dehydrogenase (NAD+) activity Cellular component • endoplasmic reticulum membrane • integral component of membrane Biological process • in utero embryonic development • placenta development • steroid biosynthetic process • response to retinoic acid • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3294	15486
Ensembl	ENSG00000086696	ENSMUSG00000031844
UniProt	P37059	P51658
RefSeq (mRNA)	NM_002153	NM_008290
RefSeq (protein)	NP_002144	NP_032316
Location (UCSC)	Chr 16: 82.04 – 82.1 Mb	Chr 8: 117.7 – 117.76 Mb
PubMed search

Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.^[1][2][3]

References

1. Durocher F, Morissette J, Labrie Y, Labrie F, Simard J (Feb 1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2". Genomics 25 (3): 724–6. doi:10.1016/0888-7543(95)80017-G. PMID 7759109.
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Mar 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
3. "Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2".

Further reading

• Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F (Oct 1995). "The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species". DNA and Cell Biology 14 (10): 849–61. doi:10.1089/dna.1995.14.849. PMID 7546291.
• Andersson S, Geissler WM, Patel S, Wu L (Jun 1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases". The Journal of Steroid Biochemistry and Molecular Biology 53 (1-6): 37–9. doi:10.1016/0960-0760(95)00039-3. PMID 7626483.
• Carsol JL, Martin PM, de Launoit Y (Oct 1994). "Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors". Neuroendocrinology 60 (4): 445–51. doi:10.1159/000126779. PMID 7824086.
• Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S (Jun 1993). "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry 268 (17): 12964–9. PMID 8099587.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Zhang Y, Word RA, Fesmire S, Carr BR, Rainey WE (Oct 1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3". The Journal of Clinical Endocrinology and Metabolism 81 (10): 3594–8. doi:10.1210/jc.81.10.3594. PMID 8855807.
• Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver". The Journal of Clinical Endocrinology and Metabolism 82 (11): 3872–8. doi:10.1210/jc.82.11.3872. PMID 9360554.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Corbould AM, Judd SJ, Rodgers RJ (Jan 1998). "Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women". The Journal of Clinical Endocrinology and Metabolism 83 (1): 187–94. doi:10.1210/jc.83.1.187. PMID 9435439.
• Dong Y, Qiu QQ, Debear J, Lathrop WF, Bertolini DR, Tamburini PP (Oct 1998). "17Beta-hydroxysteroid dehydrogenases in human bone cells". Journal of Bone and Mineral Research 13 (10): 1539–46. doi:10.1359/jbmr.1998.13.10.1539. PMID 9783542.
• Kitawaki J, Koshiba H, Ishihara H, Kusuki I, Tsukamoto K, Honjo H (Sep 2000). "Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium". The Journal of Clinical Endocrinology and Metabolism 85 (9): 3292–6. doi:10.1210/jc.85.9.3292. PMID 10999824.
• Sano T, Hirasawa G, Takeyama J, Darnel AD, Suzuki T, Moriya T, Kato K, Sekine H, Ohara S, Shimosegawa T, Nakamura J, Yoshihama M, Harada N, Sasano H (Nov 2001). "17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract". Clinical Science 101 (5): 485–91. doi:10.1042/CS20010052. PMID 11672453.
• Lu ML, Huang YW, Lin SX (Jun 2002). "Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2". The Journal of Biological Chemistry 277 (25): 22123–30. doi:10.1074/jbc.M111726200. PMID 11940569.
• Provost PR, Blomquist CH, Drolet R, Flamand N, Tremblay Y (Aug 2002). "Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation". The Journal of Clinical Endocrinology and Metabolism 87 (8): 3883–92. doi:10.1210/jc.87.8.3883. PMID 12161528.
• Oliveira IO, Lhullier C, Brum IS, Spritzer PM (Sep 2003). "Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women". Steroids 68 (7-8): 641–9. doi:10.1016/S0039-128X(03)00093-X. PMID 12957669.
• Oduwole OO, Mäkinen JM, Isomaa VV, Karttunen TJ, Vihko PT (2004). "Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues". Anticancer Research 23 (5A): 3889–97. PMID 14666693.
• Matsuzaki S, Canis M, Pouly JL, Déchelotte PJ, Mage G (Feb 2006). "Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection". Fertility and Sterility 85 (2): 308–13. doi:10.1016/j.fertnstert.2005.08.017. PMID 16595205.