HSPH1

Heat shock 105kDa/110kDa protein 1
Identifiers
Symbols	HSPH1 ; HSP105; HSP105A; HSP105B; NY-CO-25
External IDs	OMIM: 610703 MGI: 105053 HomoloGene: 21322 GeneCards: HSPH1 Gene
Gene ontology Molecular function • protein binding • ATP binding • alpha-tubulin binding Cellular component • extracellular region • nucleoplasm • cytoplasm • cytosol • microtubule • extracellular exosome • endocytic vesicle lumen Biological process • receptor-mediated endocytosis • response to unfolded protein • cellular response to heat • positive regulation of MHC class I biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • chaperone mediated protein folding requiring cofactor • positive regulation of NK T cell activation • positive regulation of protein tyrosine kinase activity • regulation of cellular response to heat • negative regulation of establishment of protein localization to mitochondrion • negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide • negative regulation of p38MAPK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10808	15505
Ensembl	ENSG00000120694	ENSMUSG00000029657
UniProt	Q92598	Q61699
RefSeq (mRNA)	NM_001286503	NM_013559
RefSeq (protein)	NP_001273432	NP_038587
Location (UCSC)	Chr 13: 31.13 – 31.16 Mb	Chr 5: 149.62 – 149.64 Mb
PubMed search

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.^[1][2][3]

Interactions

HSPH1 has been shown to interact with Cofilin 1.^[4]

References

1. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
2. Ishihara K, Yasuda K, Hatayama T (Mar 1999). "Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105". Biochim Biophys Acta 1444 (1): 138–42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472.
3. "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1".
4. Saito, Youhei; Doi Kazuya; Yamagishi Nobuyuki; Ishihara Keiichi; Hatayama Takumi (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. (United States) 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. ISSN 0006-291X. PMID 14733918.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Hatayama T, Yasuda K, Yasuda K (1998). "Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells.". Biochem. Biophys. Res. Commun. 248 (2): 395–401. doi:10.1006/bbrc.1998.8979. PMID 9675148.
• Ishihara K, Yasuda K, Hatayama T (2000). "Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II.". Biochem. Biophys. Res. Commun. 270 (3): 927–31. doi:10.1006/bbrc.2000.2541. PMID 10772927.
• Hylander BL, Chen X, Graf PC, Subjeck JR (2000). "The distribution and localization of hsp110 in brain.". Brain Res. 869 (1–2): 49–55. doi:10.1016/S0006-8993(00)02346-5. PMID 10865058.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ishihara K, Yamagishi N, Hatayama T (2003). "Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function". Biochem. J. 371 (Pt 3): 917–25. doi:10.1042/BJ20021331. PMC 1223342. PMID 12558502.
• Saito Y, Yamagishi N, Ishihara K, Hatayama T (2003). "Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system". Exp. Cell Res. 286 (2): 233–40. doi:10.1016/S0014-4827(03)00054-5. PMID 12749852.
• Chen WF, Huang MH, Tzang CH, et al. (2003). "Inhibitory actions of genistein in human breast cancer (MCF-7) cells". Biochim. Biophys. Acta 1638 (2): 187–96. doi:10.1016/s0925-4439(03)00082-6. PMID 12853125.
• Kai M, Nakatsura T, Egami H, et al. (2004). "Heat shock protein 105 is overexpressed in a variety of human tumors". Oncol. Rep. 10 (6): 1777–82. doi:10.3892/or.10.6.1777. PMID 14534695.
• Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
• Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Miyazaki M, Nakatsura T, Yokomine K, et al. (2005). "DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells". Cancer Sci. 96 (10): 695–705. doi:10.1111/j.1349-7006.2005.00093.x. PMID 16232202.