HUWE1

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Rendering based on PDB 2EKK​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EKK​, 3G1N​, 3H1D​
Identifiers
Symbols	HUWE1 ; ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE-B1; UREB1
External IDs	OMIM: 300697 MGI: 1926884 HomoloGene: 45994 GeneCards: HUWE1 Gene
Gene ontology Molecular function • DNA binding • ubiquitin-protein transferase activity • protein binding • ligase activity • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • cytoplasm • membrane • extracellular exosome Biological process • protein polyubiquitination • base-excision repair • protein monoubiquitination • histone ubiquitination • cell differentiation • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10075	59026
Ensembl	ENSG00000086758	ENSMUSG00000025261
UniProt	Q7Z6Z7	Q7TMY8
RefSeq (mRNA)	NM_031407	NM_021523
RefSeq (protein)	NP_113584	NP_067498
Location (UCSC)	Chr X: 53.53 – 53.69 Mb	Chr X: 151.8 – 151.94 Mb
PubMed search

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.^[1][2][3]

References

1. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
2. Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (Nov 2000). "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases". Trends Cell Biol 10 (10): 429–39. doi:10.1016/S0962-8924(00)01834-1. PMID 10998601.
3. "Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1".

Further reading

• Gu J, Dubner R, Fornace AJ, Iadarola MJ (1995). "UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.". Oncogene 11 (10): 2175–8. PMID 7478539.
• Gu J, Ren K, Dubner R, Iadarola MJ (1994). "Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene.". Brain Res. Mol. Brain Res. 24 (1–4): 77–88. doi:10.1016/0169-328X(94)90120-1. PMID 7968380.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoon SY, Lee Y, Kim JH, et al. (2005). "Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein". Biochem. Biophys. Res. Commun. 326 (1): 7–17. doi:10.1016/j.bbrc.2004.11.004. PMID 15567145.
• Liu Z, Oughtred R, Wing SS (2005). "Characterization of E3Histone, a Novel Testis Ubiquitin Protein Ligase Which Ubiquitinates Histones". Mol. Cell. Biol. 25 (7): 2819–31. doi:10.1128/MCB.25.7.2819-2831.2005. PMC 1061639. PMID 15767685.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Chen D, Kon N, Li M, et al. (2005). "ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor". Cell 121 (7): 1071–83. doi:10.1016/j.cell.2005.03.037. PMID 15989956.
• Zhong Q, Gao W, Du F, Wang X (2005). "Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis". Cell 121 (7): 1085–95. doi:10.1016/j.cell.2005.06.009. PMID 15989957.
• Warr MR, Acoca S, Liu Z, et al. (2005). "BH3-ligand regulates access of MCL-1 to its E3 ligase". FEBS Lett. 579 (25): 5603–8. doi:10.1016/j.febslet.2005.09.028. PMID 16213503.
• Adhikary S, Marinoni F, Hock A, et al. (2005). "The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation". Cell 123 (3): 409–21. doi:10.1016/j.cell.2005.08.016. PMID 16269333.

External links

• HUWE1 human gene location in the UCSC Genome Browser.
• HUWE1 human gene details in the UCSC Genome Browser.