HYAL3
| Hyaluronoglucosaminidase 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | HYAL3 ; HYAL-3; LUCA-3; LUCA3 | ||||||||||||
| External IDs | OMIM: 604038 MGI: 1330288 HomoloGene: 2626 GeneCards: HYAL3 Gene | ||||||||||||
| EC number | 3.2.1.35 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8372 | 109685 | |||||||||||
| Ensembl | ENSG00000186792 | ENSMUSG00000036091 | |||||||||||
| UniProt | O43820 | Q8VEI3 | |||||||||||
| RefSeq (mRNA) | NM_001200029 | NM_178020 | |||||||||||
| RefSeq (protein) | NP_001186958 | NP_821139 | |||||||||||
| Location (UCSC) |
Chr 3: 50.29 – 50.3 Mb |
Chr 9: 107.58 – 107.59 Mb | |||||||||||
| PubMed search | |||||||||||||
Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.[1][2]
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[2]
References
- ↑ Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.
- 1 2 "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".
Further reading
- Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16. doi:10.3892/or.10.3.609. PMID 12684632.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lokeshwar VB, Schroeder GL, Carey RI, et al. (2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654–63. doi:10.1074/jbc.M203821200. PMID 12084718.
- Shuttleworth TL, Wilson MD, Wicklow BA, et al. (2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". J. Biol. Chem. 277 (25): 23008–18. doi:10.1074/jbc.M108991200. PMID 11929860.
- Triggs-Raine B, Salo TJ, Zhang H, et al. (1999). "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6296–300. doi:10.1073/pnas.96.11.6296. PMC 26875. PMID 10339581.
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