Heme ligase
Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).[1] This enzyme catalyses the following chemical reaction
- 2 ferriprotoporphyrin IX
beta-hematin
This heme detoxifying enzyme is found in Plasmodium parasites.
References
- ↑ Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S. and Rathore, D. (2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathog. 4: e1000053–e1000053. doi:10.1371/journal.ppat.1000053. PMC: 2291572. PMID 18437218.
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