Heme ligase

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).^[1] This enzyme catalyses the following chemical reaction

2 ferriprotoporphyrin IX

\rightleftharpoons

beta-hematin

This heme detoxifying enzyme is found in Plasmodium parasites.

References

↑ Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S. and Rathore, D. (2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathog. 4: e1000053–e1000053. doi:10.1371/journal.ppat.1000053. PMC: 2291572. PMID 18437218.

External links

Heme ligase at the US National Library of Medicine Medical Subject Headings (MeSH)

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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