Hepsin

Hepsin
Identifiers
EC number 3.4.21.106
CAS number 112398-23-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hepsin (EC 3.4.21.106) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys

This type-II membrane-associated serine peptidase plays a role in cell growth and development.

References

  1. ↑ Zhukov, A., Hellman, U. and Ingelman-Sundberg, M. (1997). "Purification and characterization of hepsin from rat liver microsomes". Biochim. Biophys. Acta 1337 (1): 85–95. doi:10.1016/s0167-4838(96)00152-5. PMID 9003440.
  2. ↑ Kazama, Y., Hamamoto, T., Foster, D.C. and Kisiel, W. (1995). "Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation". J. Biol. Chem. 270: 66–72. doi:10.1074/jbc.270.1.66. PMID 7814421.
  3. ↑ Torres-Rosado, A., O'Shea, K.S., Tsuji, A., Chou, S.H. and Kurachi, K. (1993). "Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth". Proc. Natl. Acad. Sci. USA 90: 7181–7185. doi:10.1073/pnas.90.15.7181. PMC 47100. PMID 8346233.

See also

External links

This article is issued from Wikipedia - version of the Monday, January 25, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.