Human mammary tumor virus

Human mammary tumor virus
Virus classification
Group:	Group VI (ssRNA-RT)
Order:	Unassigned
Family:	Retroviridae
Subfamily:	Orthoretrovirinae
Genus:	Betaretrovirus
Species:	Human mammary tumor virus

Human mammary tumor virus (HMTV) is a B-type retrovirus that is closely related to the mouse mammary tumor virus (MMTV).^[1] The existence of this virus was suspected for decades^[2] but nucleotide sequences identifying a unique virus in human breast cancer tumors were not confirmed until 2001.^[3] Viral particles were isolated several years later.^[4] Evidence for a role of HTMV/MMTV in human breast cancer has recently been reviewed.^[5]

References

1. Nartey, Teiko; Moran, Heberth; Marin, Tania; Arcaro, Kathleen F; Anderton, Douglas L; Etkind, Polly; Holland, James F; Melana, Stella M; Pogo, Beatriz G-T (2014). "Human Mammary Tumor Virus (HMTV) sequences in human milk". Infectious Agents and Cancer 9 (1): 20. doi:10.1186/1750-9378-9-20.
2. Moore, Dan H.; Sarkar, Nurul H.; Kramarsky, Bernhard; Lasfargues, E. Y.; Charney, Jesse (December 1971). "Some aspects of the search for a human mammary tumor virus". Cancer 28 (6): 1415–1424. doi:10.1002/1097-0142(197112)28:6<1415::AID-CNCR2820280614>3.0.CO;2-Z.
3. Liu, B; Wang, Y; Melana, SM; Pelisson, I; Najfeld, V; Holland, JF; Pogo, BG (15 February 2001). "Identification of a proviral structure in human breast cancer.". Cancer Research 61 (4): 1754–9. PMID 11245493.
4. Melana, SM; Nepomnaschy, I; Sakalian, M; Abbott, A; Hasa, J; Holland, JF; Pogo, BG (15 September 2007). "Characterization of viral particles isolated from primary cultures of human breast cancer cells.". Cancer Research 67 (18): 8960–5. doi:10.1158/0008-5472.CAN-06-3892. PMID 17875739.
5. Salmons, Brian; Lawson, James S.; Gunzburg, Walter H. (December 2014). "Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?.". Journal of General Virology 95 (12): 2589–93. doi:10.1099/vir.0.070631-0.