HycI peptidase

This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of hydrogenase 3 in Escherichia coli by cleavage at the C-terminal side of Arg⁵³⁷.

This enzyme belongs to the peptidase family A31.

References

↑ Theodoratou, E., Paschos, A., Magalon, A., Fritsche, E., Huber, R. and Bock, A. (2000). "Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation". Eur. J. Biochem. 267: 1995–1999. doi:10.1046/j.1432-1327.2000.01202.x. PMID 10727938.
↑ Yang, F., Hu, W., Xu, H., Li, C., Xia, B. and Jin, C. (2007). "Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation". J. Biol. Chem. 282: 3856–3863. doi:10.1074/jbc.m609263200. PMID 17150961.

External links

HycI peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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