IER3

Immediate early response 3
Identifiers
Symbols	IER3 ; DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1
External IDs	OMIM: 602996 MGI: 104814 HomoloGene: 2894 GeneCards: IER3 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • integral component of membrane Biological process • response to protozoan • negative regulation of systemic arterial blood pressure • regulation of DNA repair • apoptotic process • mitotic G2 DNA damage checkpoint • intrinsic apoptotic signaling pathway in response to DNA damage • anatomical structure morphogenesis • negative regulation of apoptotic process • positive regulation of protein catabolic process • negative regulation of glycolytic process • regulation of nucleocytoplasmic transport • negative regulation of inflammatory response • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • regulation of reactive oxygen species metabolic process • regulation of response to DNA damage stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8870	15937
Ensembl	ENSG00000137331	ENSMUSG00000003541
UniProt	P46695	P46694
RefSeq (mRNA)	NM_003897	NM_133662
RefSeq (protein)	NP_003888	NP_598423
Location (UCSC)	Chr 6: 30.74 – 30.74 Mb	Chr 17: 35.82 – 35.82 Mb
PubMed search

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.^[1][2]

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.^[3]

References

1. Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res 56 (7): 1498–502. PMID 8603392.
2. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID 9703517.
3. "Entrez Gene: IER3 immediate early response 3".

Further reading

• Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis.". Apoptosis 8 (1): 11–8. doi:10.1023/A:1021688600370. PMID 12510147.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Schäfer H, Trauzold A, Siegel EG, et al. (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.". Cancer Res. 56 (11): 2641–8. PMID 8653710.
• Pietzsch A, Büchler C, Aslanidis C, Schmitz G (1997). "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine.". Biochem. Biophys. Res. Commun. 235 (1): 4–9. doi:10.1006/bbrc.1997.6715. PMID 9196025.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pietzsch A, Büchler C, Schmitz G (1998). "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene.". Biochem. Biophys. Res. Commun. 245 (3): 651–7. doi:10.1006/bbrc.1998.8500. PMID 9588170.
• Schäfer H, Diebel J, Arlt A, et al. (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.". FEBS Lett. 436 (2): 139–43. doi:10.1016/S0014-5793(98)01109-0. PMID 9781666.
• Kobayashi T, Pittelkow MR, Warner GM, et al. (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3.". Biochem. Biophys. Res. Commun. 251 (3): 868–73. doi:10.1006/bbrc.1998.9556. PMID 9791001.
• Kumar R, Kobayashi T, Warner GM, et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes.". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID 9878538.
• Schäfer H, Arlt A, Trauzold A, et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo.". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID 10448082.
• Feldmann KA, Pittelkow MR, Roche PC, et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues.". Histochem. Cell Biol. 115 (6): 489–97. doi:10.1007/s004180100284. PMID 11455449.
• Zhang Y, Schlossman SF, Edwards RA, et al. (2002). "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 878–83. doi:10.1073/pnas.022326699. PMC 117399. PMID 11782530.
• Im HJ, Pittelkow MR, Kumar R (2002). "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1.". J. Biol. Chem. 277 (17): 14612–21. doi:10.1074/jbc.M109414200. PMC 2895739. PMID 11844788.
• Ohki R, Yamamoto K, Mano H, et al. (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays.". J. Hypertens. 20 (4): 685–91. doi:10.1097/00004872-200204000-00026. PMID 11910304.
• Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression.". Oncogene 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID 12032839.
• Garcia J, Ye Y, Arranz V, et al. (2002). "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.". EMBO J. 21 (19): 5151–63. doi:10.1093/emboj/cdf488. PMC 129026. PMID 12356731.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.