IFNA10

Interferon, alpha 10
Identifiers
Symbols	IFNA10 ; IFN-alphaC
External IDs	OMIM: 147577 MGI: 2667155 HomoloGene: 136753 GeneCards: IFNA10 Gene
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding Cellular component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • blood coagulation • cytokine-mediated signaling pathway • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • B cell proliferation • response to exogenous dsRNA • innate immune response • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3446	230396
Ensembl	ENSG00000186803	ENSMUSG00000063376
UniProt	P01566	n/a
RefSeq (mRNA)	NM_002171	NM_177347
RefSeq (protein)	NP_002162	NP_796321
Location (UCSC)	Chr 9: 21.21 – 21.21 Mb	Chr 4: 88.12 – 88.12 Mb
PubMed search

Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene.^[1][2]

References

1. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
2. "Entrez Gene: IFNA10 interferon, alpha 10".

Further reading

• Bartholomew C, Windass JD (1989). "Identification of a functional allele of a human interferon-alpha gene previously characterized as a pseudogene.". J. Interferon Res. 9 (4): 407–17. doi:10.1089/jir.1989.9.407. PMID 2526839.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs.". Nature 290 (5801): 20–6. doi:10.1038/290020a0. PMID 6163083.
• Ullrich A, Gray A, Goeddel DV, Dull TJ (1982). "Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster.". J. Mol. Biol. 156 (3): 467–86. doi:10.1016/0022-2836(82)90261-3. PMID 6181262.
• Fuke M, Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon.". Gene 32 (1-2): 135–40. doi:10.1016/0378-1119(84)90041-6. PMID 6397400.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.". Biochem. J. 329 (2): 295–302. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.