IFNA17

Interferon, alpha 17
Identifiers
Symbols	IFNA17 ; IFN-alphaI; IFNA; INFA; LEIF2C1
External IDs	OMIM: 147583 MGI: 3649260 HomoloGene: 117990 GeneCards: IFNA17 Gene
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding Cellular component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • blood coagulation • response to virus • cytokine-mediated signaling pathway • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • B cell proliferation • response to exogenous dsRNA • innate immune response • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3451	230398
Ensembl	ENSG00000234829	ENSMUSG00000063916
UniProt	P01571	n/a
RefSeq (mRNA)	NM_021268	NM_206867
RefSeq (protein)	NP_067091	NP_996750
Location (UCSC)	Chr 9: 21.21 – 21.23 Mb	Chr 4: 88.15 – 88.15 Mb
PubMed search

Interferon alpha-17 is a protein that in humans is encoded by the IFNA17 gene.^[1][2]

References

1. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
2. "Entrez Gene: IFNA17 interferon, alpha 17".

Further reading

• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry.". J. Biol. Chem. 267 (8): 5017–20. PMID 1371992.
• Zoon KC, Miller D, Bekisz J, et al. (1992). "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.". J. Biol. Chem. 267 (21): 15210–6. PMID 1634550.
• Savel'ev VI, Zlochevskiĭ ML, Sorokin AV, et al. (1986). "[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]". Antibiot. Med. Biotekhnol. 31 (8): 592–6. PMID 3767336.
• Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules.". DNA 4 (3): 221–32. doi:10.1089/dna.1985.4.221. PMID 3891272.
• Lund B, von Gabain A, Edlund T, et al. (1985). "Differential expression of interferon genes in a substrain of Namalwa cells.". J. Interferon Res. 5 (2): 229–38. doi:10.1089/jir.1985.5.229. PMID 4008999.
• Lawn RM, Adelman J, Dull TJ, et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes.". Science 212 (4499): 1159–62. doi:10.1126/science.6165082. PMID 6165082.
• Fuke M, Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon.". Gene 32 (1-2): 135–40. doi:10.1016/0378-1119(84)90041-6. PMID 6397400.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.". Biochem. J. 329 (2): 295–302. PMC 1219044. PMID 9425112.
• Hussain M, Tan T, Ni D, et al. (1998). "A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population.". J. Interferon Cytokine Res. 18 (7): 469–77. doi:10.1089/jir.1998.18.469. PMID 9712362.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim JW, Roh JW, Park NH, et al. (2003). "Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk.". Cancer Lett. 189 (2): 183–8. doi:10.1016/S0304-3835(02)00548-7. PMID 12490311.