IFNA6

Interferon, alpha 6
Identifiers
Symbols	IFNA6 ; IFN-alphaK
External IDs	OMIM: 147566 HomoloGene: 105727 GeneCards: IFNA6 Gene
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding Cellular component • cellular_component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • blood coagulation • cytokine-mediated signaling pathway • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • B cell proliferation • response to exogenous dsRNA • innate immune response • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3443	n/a
Ensembl	ENSG00000120235	n/a
UniProt	P05013	n/a
RefSeq (mRNA)	NM_021002	n/a
RefSeq (protein)	NP_066282	n/a
Location (UCSC)	Chr 9: 21.35 – 21.35 Mb	n/a
PubMed search		n/a

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.^[1][2]

References

1. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
2. "Entrez Gene: IFNA6 interferon, alpha 6".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes.". Genomics 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.". Biochem. J. 329. ( Pt 2): 295–302. PMC 1219044. PMID 9425112.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.