IFNA8

Interferon, alpha 8
Identifiers
Symbols	IFNA8 ; IFN-alphaB
External IDs	OMIM: 147568 HomoloGene: 68237 GeneCards: IFNA8 Gene
Gene ontology Molecular function • cytokine activity • cytokine receptor binding • type I interferon receptor binding Cellular component • extracellular region • extracellular space Biological process • adaptive immune response • T cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • blood coagulation • cytokine-mediated signaling pathway • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • B cell proliferation • response to exogenous dsRNA • innate immune response • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3445	n/a
Ensembl	ENSG00000120242	n/a
UniProt	P32881	n/a
RefSeq (mRNA)	NM_002170	n/a
RefSeq (protein)	NP_002161	n/a
Location (UCSC)	Chr 9: 21.41 – 21.41 Mb	n/a
PubMed search		n/a

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.^[1][2]

References

1. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
2. "Entrez Gene: IFNA8 interferon, alpha 8".

Further reading

• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs.". Nature 290 (5801): 20–6. doi:10.1038/290020a0. PMID 6163083.
• Yelverton E, Leung D, Weck P, et al. (1981). "Bacterial synthesis of a novel human leukocyte interferon.". Nucleic Acids Res. 9 (3): 731–41. doi:10.1093/nar/9.3.731. PMC 327233. PMID 6164048.
• Bowden DW, Mao J, Gill T, et al. (1984). "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes.". Gene 27 (1): 87–99. doi:10.1016/0378-1119(84)90241-5. PMID 6325303.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
• Hussain M, Gill DS, Liao MJ, Testa D (1997). "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population.". J. Interferon Cytokine Res. 16 (7): 523–9. doi:10.1089/jir.1996.16.523. PMID 8836918.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.". Biochem. J. 329. ( Pt 2): 295–302. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes.". Genomics 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.