IFT74

Intraflagellar transport 74
Identifiers
Symbols	IFT74 ; CCDC2; CMG-1; CMG1
External IDs	OMIM: 608040 MGI: 1914944 HomoloGene: 11831 GeneCards: IFT74 Gene
Gene ontology Molecular function • chromatin binding • beta-tubulin binding Cellular component • nucleus • centrosome • cilium • cytoplasmic membrane-bounded vesicle • intraciliary transport particle B • motile cilium • primary cilium • ciliary tip Biological process • keratinocyte development • organelle organization • Notch signaling pathway • positive regulation of cell adhesion mediated by integrin • intraciliary transport involved in cilium morphogenesis • cilium assembly • positive regulation of transcription from RNA polymerase II promoter • negative regulation of epithelial cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80173	67694
Ensembl	ENSG00000096872	ENSMUSG00000028576
UniProt	Q96LB3	Q8BKE9
RefSeq (mRNA)	NM_001099222	NM_001290568
RefSeq (protein)	NP_001092692	NP_001277497
Location (UCSC)	Chr 9: 26.95 – 27.06 Mb	Chr 4: 94.61 – 94.69 Mb
PubMed search

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.^[1][2]

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.^[2]

References

1. "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
2. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell. Sci. 114 (Pt 15): 2755–73. PMID 11683410.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.". Neurobiol. Aging 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.