IGHG3

Immunoglobulin heavy constant gamma 3 (G3m marker)
Identifiers
Symbols	IGHG3 ; IgG3
External IDs	OMIM: 147120 GeneCards: IGHG3 Gene
Gene ontology Molecular function • antigen binding Cellular component • extracellular region • membrane Biological process • immune response • complement activation • complement activation, classical pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response
Orthologs
Species	Human	Mouse
Entrez	3502	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.^[1][2]

References

1. Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A 79 (10): 3260–4. doi:10.1073/pnas.79.10.3260. PMC 346395. PMID 6808505.
2. "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

Further reading

• Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.". J. Biol. Chem. 252 (3): 883–9. PMID 402363.
• Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3.". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
• Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572. PMID 3081877.
• Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis.". Biochemistry 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
• Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody.". J. Immunol. 151 (5): 2829–38. PMID 8395549.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.