IHPK2

Inositol hexakisphosphate kinase 2
Identifiers
Symbols	IP6K2 ; IHPK2; PIUS
External IDs	OMIM: 606992 MGI: 1923750 HomoloGene: 56929 GeneCards: IP6K2 Gene
EC number	2.7.4.21
Gene ontology Molecular function • inositol hexakisphosphate 5-kinase activity • protein binding • ATP binding • inositol-1,4,5-trisphosphate 3-kinase activity • inositol hexakisphosphate 1-kinase activity • inositol hexakisphosphate 3-kinase activity Cellular component • nucleus • nucleoplasm • intermediate filament cytoskeleton Biological process • phosphate ion transport • cytokine-mediated signaling pathway • negative regulation of cell growth • positive regulation of apoptotic process • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol phosphorylation • type I interferon signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51447	76500
Ensembl	ENSG00000068745	ENSMUSG00000032599
UniProt	Q9UHH9	Q80V72
RefSeq (mRNA)	NM_001005909	NM_029634
RefSeq (protein)	NP_001005909	NP_083910
Location (UCSC)	Chr 3: 48.69 – 48.74 Mb	Chr 9: 108.78 – 108.81 Mb
PubMed search

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.^[1][2]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.^[2]

References

1. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (May 2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr Biol 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
2. "Entrez Gene: IHPK2 inositol hexaphosphate kinase 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3.". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID 9776982.
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
• Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ (2001). "Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.". J. Biol. Chem. 276 (27): 24965–70. doi:10.1074/jbc.M101161200. PMC 2025680. PMID 11337497.
• Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase.". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
• Morrison BH, Bauer JA, Hu J, et al. (2002). "Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.". Oncogene 21 (12): 1882–9. doi:10.1038/sj.onc.1205265. PMC 2043497. PMID 11896621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nagata E, Luo HR, Saiardi A, et al. (2005). "Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.". J. Biol. Chem. 280 (2): 1634–40. doi:10.1074/jbc.M409416200. PMID 15533939.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Morrison BH, Bauer JA, Lupica JA, et al. (2007). "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.". J. Biol. Chem. 282 (21): 15349–56. doi:10.1074/jbc.M700156200. PMC 2048714. PMID 17379600.

See also

• Inositol-hexakisphosphate kinase