IL1RL2

Interleukin 1 receptor-like 2
Identifiers
Symbols	IL1RL2 ; IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2
External IDs	OMIM: 604512 MGI: 1913107 HomoloGene: 2860 GeneCards: IL1RL2 Gene
Gene ontology Molecular function • interleukin-1 receptor activity • interleukin-1, Type I, activating receptor activity Cellular component • integral component of plasma membrane Biological process • inflammatory response • cellular defense response • signal transduction • cytokine-mediated signaling pathway • positive regulation of interleukin-6 production • innate immune response • positive regulation of T cell differentiation • regulation of inflammatory response • interleukin-1-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8808	107527
Ensembl	ENSG00000115598	ENSMUSG00000070942
UniProt	Q9HB29	Q9ERS7
RefSeq (mRNA)	NM_003854	NM_133193
RefSeq (protein)	NP_003845	NP_573456
Location (UCSC)	Chr 2: 102.19 – 102.24 Mb	Chr 1: 40.32 – 40.37 Mb
PubMed search

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.^[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[4]

References

1. Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
2. Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
3. Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
4. "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

Further reading

• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184.
• Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.". Science 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913.
• Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
• Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis.". Seizure : the journal of the British Epilepsy Association 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.