IL17RB
| Interleukin 17 receptor B | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IL17RB ; CRL4; EVI27; IL17BR; IL17RH1 | ||||||||||||
| External IDs | OMIM: 605458 MGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55540 | 50905 | |||||||||||
| Ensembl | ENSG00000056736 | ENSMUSG00000015966 | |||||||||||
| UniProt | Q9NRM6 | Q9JIP3 | |||||||||||
| RefSeq (mRNA) | NM_018725 | NM_019583 | |||||||||||
| RefSeq (protein) | NP_061195 | NP_062529 | |||||||||||
| Location (UCSC) |
Chr 3: 53.85 – 53.87 Mb |
Chr 14: 30 – 30.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[1][2][3]
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[3]
See also
References
- ↑ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
- ↑ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr
title = Evi27 encodes a novel membrane protein with homology to the IL17 receptor (Jun 2000). Oncogene 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. line feed character in
|author=at position 79 (help); Missing or empty|title=(help) - 1 2 "Entrez Gene: IL17RB interleukin 17 receptor B".
Further reading
- Schwandner R, Yamaguchi K, Cao Z (2000). "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction.". J. Exp. Med. 191 (7): 1233–40. doi:10.1084/jem.191.7.1233. PMC 2193168. PMID 10748240.
- Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.". J. Biol. Chem. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy.". Clin. Cancer Res. 12 (7 Pt 1): 1954–5. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
- Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen.". Clin. Cancer Res. 12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019.
- Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.". J. Clin. Oncol. 24 (28): 4611–9. doi:10.1200/JCO.2006.06.6944. PMID 17008703.
External links
- IL17RB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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