ILPR

The insulin-linked polymorphic region (ILPR) is a regulatory sequence on the insulin gene starting at position -363 upstream from the transcriptional start location of the 5' region and consists of multiple repeats of a ACA-GGGGT(G/C)(T/C)GGG consensus sequence.^[1] The polymorphic aspect of this region is due to three possible combinations of sequences according to their length: 700bp, 1600bp and 2500bp.

References

↑ Hammond-Kosack, M C; B Dobrinski; R Lurz; K Docherty; M W Kilpatrick (January 25, 1992). "The human insulin gene linked polymorphic region exhibits an altered DNA structure". Nucleic Acids Res. 20 (2): 231–6. doi:10.1093/nar/20.2.231. PMC 310359. PMID 1741248.

Regulatory sequences

General	CAAT box CCAAT box Pribnow box TATA box SECIS element A-box Z-box C-box E-box G-box

Insulin gene	A5 Z negative regulatory element C2 E2 A3 cAMP response element A2 CAAT enhancer binding (CEB) C1 E1 G1 - ILPR

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