INHBC

Inhibin, beta C
Identifiers
Symbols	INHBC ; IHBC
External IDs	OMIM: 601233 MGI: 105932 HomoloGene: 21142 GeneCards: INHBC Gene
Gene ontology Molecular function • cytokine activity • transforming growth factor beta receptor binding • hormone activity • growth factor activity Cellular component • extracellular region • extracellular space • extracellular exosome Biological process • positive regulation of pathway-restricted SMAD protein phosphorylation • growth • regulation of apoptotic process • regulation of MAPK cascade • cell development • SMAD protein signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3626	16325
Ensembl	ENSG00000175189	ENSMUSG00000025405
UniProt	P55103	P55104
RefSeq (mRNA)	NM_005538	NM_010565
RefSeq (protein)	NP_005529	NP_034695
Location (UCSC)	Chr 12: 57.43 – 57.45 Mb	Chr 10: 127.36 – 127.37 Mb
PubMed search

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.^[1][2]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.^[2]

References

1. H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.
2. "Entrez Gene: INHBC inhibin, beta C".

Further reading

• Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction.". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224.
• Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase.". Cell 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080.
• Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.". Genomics 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799.
• Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.". Prostate 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386.
• Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jc.85.12.4851. PMID 11134153.
• Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901.
• Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.". Endocrinology 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042.
• Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein.". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.