INPP4B

Inositol polyphosphate-4-phosphatase type II B
Identifiers
Symbol	INPP4B
External IDs	OMIM: 607494 HomoloGene: 20832 GeneCards: INPP4B Gene
EC number	3.1.3.66
Gene ontology Molecular function • protein binding • lipid binding • phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity • phosphatidylinositol trisphosphate phosphatase activity • phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Cellular component • cytosol Biological process • protein dephosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • cellular calcium ion homeostasis • signal transduction • phosphatidylinositol-3-phosphate biosynthetic process • inositol phosphate metabolic process • small molecule metabolic process • negative regulation of osteoclast differentiation • regulation of nucleocytoplasmic transport • regulation of bone remodeling • regulation of protein kinase B signaling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8821	234515
Ensembl	ENSG00000109452	ENSMUSG00000037940
UniProt	O15327	Q6P1Y8
RefSeq (mRNA)	NM_001101669	NM_001024617
RefSeq (protein)	NP_001095139	NP_001019788
Location (UCSC)	Chr 4: 142.02 – 142.85 Mb	Chr 8: 81.34 – 82.13 Mb
PubMed search

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.^[1]

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.^[1]

References

1. "Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa". Retrieved 2012-07-24.

Further reading

• Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU (Oct 2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications 440 (2): 277–82. doi:10.1016/j.bbrc.2013.09.077. PMID 24070612.* Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC (Aug 2009). "Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling". Cancer Cell 16 (2): 115–25. doi:10.1016/j.ccr.2009.06.006. PMC 2957372. PMID 19647222.
• Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU (Jan 2011). "Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer". Cancer Research 71 (2): 572–82. doi:10.1158/0008-5472.CAN-10-2314. PMC 3077543. PMID 21224358.
• Norris FA, Atkins RC, Majerus PW (Sep 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". The Journal of Biological Chemistry 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.
• Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA (Mar 1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proceedings of the National Academy of Sciences of the United States of America 96 (7): 3640–5. doi:10.1073/pnas.96.7.3640. PMC 22347. PMID 10097090.
• Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S (2010). "Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation". BMC Evolutionary Biology 10: 351. doi:10.1186/1471-2148-10-351. PMC 2996405. PMID 21070662.
• Norris FA, Auethavekiat V, Majerus PW (Jul 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". The Journal of Biological Chemistry 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
• Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR (Dec 2007). "Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations". Diabetes 56 (12): 3053–62. doi:10.2337/db07-0457. PMID 17846126.
• Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA (Dec 2010). "Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22231–6. doi:10.1073/pnas.1015245107. PMC 3009830. PMID 21127264.
• Zhang X, Majerus PW (Apr 1998). "Phosphatidylinositol signalling reactions". Seminars in Cell & Developmental Biology 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
• Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM (Apr 2011). "INPP4B: the new kid on the PI3K block". Oncotarget 2 (4): 321–8. doi:10.18632/oncotarget.260. PMC 3248162. PMID 21487159.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.