INPP5A

Inositol polyphosphate-5-phosphatase A
Identifiers
Symbols	INPP5A ; 5PTASE
External IDs	OMIM: 600106 MGI: 2686961 HomoloGene: 4045 IUPHAR: 1453 ChEMBL: 4243 GeneCards: INPP5A Gene
EC number	3.1.3.56
Gene ontology Molecular function • inositol-polyphosphate 5-phosphatase activity • protein binding • PH domain binding • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component • plasma membrane • membrane • extracellular exosome Biological process • protein dephosphorylation • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3632	212111
Ensembl	ENSG00000068383	ENSMUSG00000025477
UniProt	Q14642	E9QAS7
RefSeq (mRNA)	NM_005539	NM_001127363
RefSeq (protein)	NP_005530	NP_001120835
Location (UCSC)	Chr 10: 132.54 – 132.78 Mb	Chr 7: 139.39 – 139.58 Mb
PubMed search

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.^[1][2]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.^[2]

References

1. De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID 8013665.
2. "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

Further reading

• Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase.". J. Biol. Chem. 269 (25): 17305–10. PMID 8006039.
• Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization.". Genomics 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID 8808294.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I.". J. Biol. Chem. 272 (3): 1786–90. doi:10.1074/jbc.272.3.1786. PMID 8999861.
• Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta.". Biochemistry 36 (49): 15363–70. doi:10.1021/bi9708085. PMID 9398266.
• Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.". Mamm. Genome 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.